dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000925
Uniprot Accession O15304; SIVA_HUMAN; Q96P98; Q9UPD6;
Genbank Protein ID NP_006418.2; NP_068355.1;
Genbank Nucleotide ID NM_006427.3; NM_021709.2;
Protein Name Apoptosis regulatory protein Siva
Protein Synonyms/Alias CD27-binding protein;CD27BP;
Gene Name SIVA1
Gene Synonyms/Alias SIVA;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
5---MPKRSCPFADVAPhosphoSitePlus;curated22135298; 25627689
34RGVCAERYSQEVFEKdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated11278261; 16381945; 23193290; 22135298; 22817900; 24260401
53LFLGAQAYLDHVWDEdbPTM 3.0;PhosphoSitePlus;curated20727854; 16381945; 23193290; 22135298; 22817900
70AVVHLPESPKPGPTGPhosphoSitePlus;UniProt;curated22135298; 24275569; 23090842
162LVDCSDMYEKVLCTSdbPTM 3.0;PhosphoSitePlus;curated20727854; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MPKRSCPFAD VAPLQLKVRV SQRELSRGVC AERYSQEVFE KTKRLLFLGA QAYLDHVWDE 60
GCAVVHLPES PKPGPTGAPR AARGQMLIGP DGRLIRSLGQ ASEADPSGVA SIACSSCVRA 120
VDGKAVCGQC ERALCGQCVR TCWGCGSVAC TLCGLVDCSD MYEKVLCTSC AMFET 176
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0582--Pharmaceutical
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR022773--Siva_cd27-bd
PROSITE
Pfam

PF05458--Siva
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005175--F:CD27 receptor binding
GO:0046872--F:metal ion binding
GO:0001618--F:virus receptor activity
GO:0008270--F:zinc ion binding
GO:0006924--P:activation-induced cell death of T cells
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:1901030--P:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0046718--P:viral entry into host cell