| Tag |
Content |
| dbPAF ID |
dbPAF-0000924 |
| Uniprot Accession |
O15303; GRM6_HUMAN;
|
| Genbank Protein ID |
NP_000834.2;
|
| Genbank Nucleotide ID |
NM_000843.3;
|
| Protein Name |
Metabotropic glutamate receptor 6 |
| Protein Synonyms/Alias |
|
| Gene Name |
GRM6 |
| Gene Synonyms/Alias |
GPRC1F;MGLUR6; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.Functional Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MARPRRAREP LLVALLPLAW LAQAGLARAA GSVRLAGGLT LGGLFPVHAR GAAGRACGQL 60
KKEQGVHRLE AMLYALDRVN ADPELLPGVR LGARLLDTCS RDTYALEQAL SFVQALIRGR 120
GDGDEVGVRC PGGVPPLRPA PPERVVAVVG ASASSVSIMV ANVLRLFAIP QISYASTAPE 180
LSDSTRYDFF SRVVPPDSYQ AQAMVDIVRA LGWNYVSTLA SEGNYGESGV EAFVQISREA 240
GGVCIAQSIK IPREPKPGEF SKVIRRLMET PNARGIIIFA NEDDIRRVLE AARQANLTGH 300
FLWVGSDSWG AKTSPILSLE DVAVGAITIL PKRASIDGFD QYFMTRSLEN NRRNIWFAEF 360
WEENFNCKLT SSGTQSDDST RKCTGEERIG RDSTYEQEGK VQFVIDAVYA IAHALHSMHQ 420
ALCPGHTGLC PAMEPTDGRM LLQYIRAVRF NGSAGTPVMF NENGDAPGRY DIFQYQATNG 480
SASSGGYQAV GQWAETLRLD VEALQWSGDP HEVPSSLCSL PCGPGERKKM VKGVPCCWHC 540
EACDGYRFQV DEFTCEACPG DMRPTPNHTG CRPTPVVRLS WSSPWAAPPL LLAVLGIVAT 600
TTVVATFVRY NNTPIVRASG RELSYVLLTG IFLIYAITFL MVAEPGAAVC AARRLFLGLG 660
TTLSYSALLT KTNRIYRIFE QGKRSVTPPP FISPTSQLVI TFSLTSLQVV GMIAWLGARP 720
PHSVIDYEEQ RTVDPEQARG VLKCDMSDLS LIGCLGYSLL LMVTCTVYAI KARGVPETFN 780
EAKPIGFTMY TTCIIWLAFV PIFFGTAQSA EKIYIQTTTL TVSLSLSASV SLGMLYVPKT 840
YVILFHPEQN VQKRKRSLKA TSTVAAPPKG EDAEAHK
878Fasta Sequence
>O15303|GRM6|Homo sapiens(Human)
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
|
| Keyword |
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-1014--Congenital stationary night blindness
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0716--Sensory transduction
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0844--Vision
|
| Interpro |
IPR001828--ANF_lig-bd_rcpt
IPR000337--GPCR_3
IPR011500--GPCR_3_9-Cys_dom
IPR017978--GPCR_3_C
IPR017979--GPCR_3_CS
IPR000162--GPCR_3_mtglu_rcpt
IPR000112--GPCR_3_mtglu_rcpt_6
IPR028082--Peripla_BP_I
|
| PROSITE |
PS00979--G_PROTEIN_RECEP_F3_1
PS00980--G_PROTEIN_RECEP_F3_2
PS00981--G_PROTEIN_RECEP_F3_3
PS50259--G_PROTEIN_RECEP_F3_4
|
| Pfam |
PF00003--7tm_3
PF01094--ANF_receptor
PF07562--NCD3G
|
| Gene Ontology |
GO:0030425--C:dendrite
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0035841--C:new growing cell tip
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0004930--F:G-protein coupled receptor activity
GO:0008066--F:glutamate receptor activity
GO:0001642--F:group III metabotropic glutamate receptor activity
GO:0042803--F:protein homodimerization activity
GO:0007196--P:adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0050908--P:detection of light stimulus involved in visual perception
GO:0009584--P:detection of visible light
GO:0007216--P:G-protein coupled glutamate receptor signaling pathway
GO:0007626--P:locomotory behavior
GO:0090280--P:positive regulation of calcium ion import
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0060041--P:retina development in camera-type eye
GO:0007268--P:synaptic transmission
|
