dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000923
Uniprot Accession O15297; PPM1D_HUMAN; Q53XP4; Q6P991; Q8IVR6;
Genbank Protein ID NP_003611.1;
Genbank Nucleotide ID NM_003620.3;
Protein Name Protein phosphatase 1D
Protein Synonyms/Alias Protein phosphatase 2C isoform delta;PP2C-delta;Protein phosphatase magnesium-dependent 1 delta;p53-induced protein phosphatase 1;
Gene Name PPM1D
Gene Synonyms/Alias WIP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
10GLYSLGVSVFSDQGGPhosphoSitePlus22135298
34IVVEPEPTAEEKPSPcurated23898821; 26074081
40PTAEEKPSPRRSLSQdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 25627689; 23898821;
44EKPSPRRSLSQPLPPcurated26074081
46PSPRRSLSQPLPPRPPhosphoSitePlus22135298
54QPLPPRPSPAALPGGPhosphoSitePlus22135298
85PLPDAGASPAPSRCCdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19007248; 16381945; 23193290; 18988627; 22135298; 25850435;
234RIEGLGGSVMNKSGVPhosphoSitePlus22135298
239GGSVMNKSGVNRVVWPhosphoSitePlus22135298
308LDPQKHKYIILGSDGdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
432DPWPRVNSKDHIPALcurated25849741
517QKNLKMSTPGQMKAQPhosphoSitePlus22135298
529KAQEIERTPPTNFKRPhosphoSitePlus;curated22135298; 25849741
541FKRTLEESNSGPLMKPhosphoSitePlus22135298
543RTLEESNSGPLMKKHPhosphoSitePlus;curated22135298; 25849741
558RRNGLSRSSGAQPAScurated25849741
559RNGLSRSSGAQPASLcurated25849741
565SSGAQPASLPTTSQRPhosphoSitePlus22135298
570PASLPTTSQRKNSVKPhosphoSitePlus22135298
Sequence
(Fasta)		MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG 60
GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 120
WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 180
RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 240
VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 300
LDPQKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 360
RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK 420
SLEEDPWPRV NSKDHIPALV RSNAFSENFL EVSAEIAREN VQGVVIPSKD PEPLEENCAK 480
ALTLRIHDSL NNSLPIGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE 540
SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK 600
TVCVC 606
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
Interpro

IPR015655--PP2C
IPR000222--PP2C_BS
IPR001932--PPM-type_phosphatase_dom
PROSITE

PS01032--PPM_1
PS51746--PPM_2
Pfam

PF00481--PP2C
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0051019--F:mitogen-activated protein kinase binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0009267--P:cellular response to starvation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0008285--P:negative regulation of cell proliferation
GO:0035970--P:peptidyl-threonine dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0009617--P:response to bacterium
GO:0009314--P:response to radiation