| Tag |
Content |
| dbPAF ID |
dbPAF-0000922 |
| Uniprot Accession |
O15296; LX15B_HUMAN; D3DTR2; Q8IYQ2; Q8TEV3; Q8TEV4; Q8TEV5; Q8TEV6; Q9UKM4;
|
| Genbank Protein ID |
NP_001034219.1; NP_001034220.1; NP_001132.2;
|
| Genbank Nucleotide ID |
NM_001039130.1; NM_001039131.1; NM_001141.2;
|
| Protein Name |
Arachidonate 15-lipoxygenase B |
| Protein Synonyms/Alias |
|
| Gene Name |
ALOX15B |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.Functional Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED 60
VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE 120
GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK 180
NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS 240
QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT 300
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV 360
RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL 420
IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI 480
WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ 540
YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT 600
CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL 660
PYTYLDPPLI ENSVSI
677Fasta Sequence
>O15296|ALOX15B|Homo sapiens(Human)
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0223--Dioxygenase
KW-0408--Iron
KW-0443--Lipid metabolism
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
|
| Interpro |
IPR000907--LipOase
IPR013819--LipOase_C
IPR020834--LipOase_CS
IPR020833--LipOase_Fe_BS
IPR001885--LipOase_mml
IPR001024--PLAT/LH2_dom
|
| PROSITE |
PS00711--LIPOXYGENASE_1
PS00081--LIPOXYGENASE_2
PS51393--LIPOXYGENASE_3
PS50095--PLAT
|
| Pfam |
PF00305--Lipoxygenase
PF01477--PLAT
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0050473--F:arachidonate 15-lipoxygenase activity
GO:0036403--F:arachidonate 8(S)-lipoxygenase activity
GO:0005509--F:calcium ion binding
GO:0005506--F:iron ion binding
GO:0016165--F:linoleate 13S-lipoxygenase activity
GO:0008289--F:lipid binding
GO:0006915--P:apoptotic process
GO:0019369--P:arachidonic acid metabolic process
GO:0051122--P:hepoxilin biosynthetic process
GO:0043651--P:linoleic acid metabolic process
GO:0006629--P:lipid metabolic process
GO:0019372--P:lipoxygenase pathway
GO:0045786--P:negative regulation of cell cycle
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0090197--P:positive regulation of chemokine secretion
GO:0045618--P:positive regulation of keratinocyte differentiation
GO:0010744--P:positive regulation of macrophage derived foam cell differentiation
GO:0035360--P:positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0030850--P:prostate gland development
GO:0030856--P:regulation of epithelial cell differentiation
GO:0044281--P:small molecule metabolic process
|
