dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000919
Uniprot Accession O15273; TELT_HUMAN; Q96L27;
Genbank Protein ID NP_003664.1;
Genbank Nucleotide ID NM_003673.3;
Protein Name Telethonin
Protein Synonyms/Alias Titin cap protein;
Gene Name TCAP
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
Phosphorylation Sites
dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
39TRPEEGCSLHEEDTQPhosphoSitePlus22135298
102TPAKMGATKEEREDTPhosphoSitePlus22135298
147LPPVVPVSKPGALRRPhosphoSitePlus22135298
155KPGALRRSLSRSMSQPhosphoSitePlus22135298
157GALRRSLSRSMSQEAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus9804419; 16381945; 23193290; 18988627; 22135298
161RSLSRSMSQEAQRG-dbPTM 3.0;HPRD 9;PhosphoSitePlus18452278; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)
MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL 60
VQRSPWLMMR MGILGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE 120
TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG 168
Keyword

KW-0002--3D-structure
KW-0122--Cardiomyopathy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0947--Limb-girdle muscular dystrophy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR015667--Telethonin
IPR023111--Titin-like_domain

PROSITE
Pfam

PF09470--Telethonin

Gene Ontology

GO:0005829--C:cytosol
GO:0031674--C:I band
GO:0030018--C:Z disc
GO:0036122--F:BMP binding
GO:0051373--F:FATZ binding
GO:0044325--F:ion channel binding
GO:0030674--F:protein binding, bridging
GO:0008307--F:structural constituent of muscle
GO:0031432--F:titin binding
GO:0070080--F:titin Z domain binding
GO:0007512--P:adult heart development
GO:0060048--P:cardiac muscle contraction
GO:0048739--P:cardiac muscle fiber development
GO:0003300--P:cardiac muscle hypertrophy
GO:0014898--P:cardiac muscle hypertrophy in response to stress
GO:0055008--P:cardiac muscle tissue morphogenesis
GO:0055003--P:cardiac myofibril assembly
GO:0050982--P:detection of mechanical stimulus
GO:0035995--P:detection of muscle stretch
GO:0030049--P:muscle filament sliding
GO:0030916--P:otic vesicle formation
GO:0006461--P:protein complex assembly
GO:0035994--P:response to muscle stretch
GO:0045214--P:sarcomere organization
GO:0048769--P:sarcomerogenesis
GO:0003009--P:skeletal muscle contraction
GO:0030241--P:skeletal muscle myosin thick filament assembly
GO:0030240--P:skeletal muscle thin filament assembly
GO:0001756--P:somitogenesis