dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000918
Uniprot Accession O15270; SPTC2_HUMAN; Q16685;
Genbank Protein ID NP_004854.1;
Genbank Nucleotide ID NM_004863.3;
Protein Name Serine palmitoyltransferase 2
Protein Synonyms/Alias Long chain base biosynthesis protein 2;LCB 2;Long chain base biosynthesis protein 2a;LCB2a;Serine-palmitoyl-CoA transferase 2;SPT 2;
Gene Name SPTLC2
Gene Synonyms/Alias KIAA0526;LCB2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
176GVINMGSYNYLGFARPhosphoSitePlus22135298
384FTKSFGASGGYIGGKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 19060867;
387SFGASGGYIGGKKELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 19060867;
402IDYLRTHSHSAVYATPhosphoSitePlus22135298
409SHSAVYATSLSPPVVPhosphoSitePlus22135298
412AVYATSLSPPVVEQIPhosphoSitePlus22135298
432CIMGQDGTSLGKECVPhosphoSitePlus22135298
433IMGQDGTSLGKECVQPhosphoSitePlus22135298
474PVVPLMLYMPAKIGAdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
555LDRPFDETTYEETEDPhosphoSitePlus22135298
557RPFDETTYEETED--PhosphoSitePlus22135298
Sequence
(Fasta)		MRPEPGGCCC RRTVRANGCV ANGEVRNGYV RSSAAAAAAA AAGQIHHVTQ NGGLYKRPFN 60
EAFEETPMLV AVLTYVGYGV LTLFGYLRDF LRYWRIEKCH HATEREEQKD FVSLYQDFEN 120
FYTRNLYMRI RDNWNRPICS VPGARVDIME RQSHDYNWSF KYTGNIIKGV INMGSYNYLG 180
FARNTGSCQE AAAKVLEEYG AGVCSTRQEI GNLDKHEELE ELVARFLGVE AAMAYGMGFA 240
TNSMNIPALV GKGCLILSDE LNHASLVLGA RLSGATIRIF KHNNMQSLEK LLKDAIVYGQ 300
PRTRRPWKKI LILVEGIYSM EGSIVRLPEV IALKKKYKAY LYLDEAHSIG ALGPTGRGVV 360
EYFGLDPEDV DVMMGTFTKS FGASGGYIGG KKELIDYLRT HSHSAVYATS LSPPVVEQII 420
TSMKCIMGQD GTSLGKECVQ QLAENTRYFR RRLKEMGFII YGNEDSPVVP LMLYMPAKIG 480
AFGREMLKRN IGVVVVGFPA TPIIESRARF CLSAAHTKEI LDTALKEIDE VGDLLQLKYS 540
RHRLVPLLDR PFDETTYEET ED 563
Keyword

KW-0012--Acyltransferase
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0622--Neuropathy
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0746--Sphingolipid metabolism
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001917--Aminotrans_II_pyridoxalP_BS
IPR004839--Aminotransferase_I/II
IPR015424--PyrdxlP-dep_Trfase
IPR015421--PyrdxlP-dep_Trfase_major_sub1
IPR015422--PyrdxlP-dep_Trfase_major_sub2
PROSITE

PS00599--AA_TRANSFER_CLASS_2
Pfam

PF00155--Aminotran_1_2
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005739--C:mitochondrion
GO:0017059--C:serine C-palmitoyltransferase complex
GO:0030170--F:pyridoxal phosphate binding
GO:0004758--F:serine C-palmitoyltransferase activity
GO:0046513--P:ceramide biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0046511--P:sphinganine biosynthetic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process
GO:0006686--P:sphingomyelin biosynthetic process
GO:0046512--P:sphingosine biosynthetic process