dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000917
Uniprot Accession O15269; SPTC1_HUMAN; A8K681; Q5VWB4; Q96IX6;
Genbank Protein ID NP_001268232.1; NP_006406.1; NP_847894.1;
Genbank Nucleotide ID NM_001281303.1; NM_006415.3; NM_178324.2;
Protein Name Serine palmitoyltransferase 1
Protein Synonyms/Alias Long chain base biosynthesis protein 1;LCB 1;Serine-palmitoyl-CoA transferase 1;SPT 1;SPT1;
Gene Name SPTLC1
Gene Synonyms/Alias LCB1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
44RLLFSKTYKLQERSDdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
50TYKLQERSDLTVKEKdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 25627689; 22817900
53LQERSDLTVKEKEELdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
82KDHPALNYNIVSGPPdbPTM 3.0;PhosphoSitePlus;curated18083107; 18180459; 20736484; 16381945; 23193290; 22135298;
164KTEEAIIYSYGFATIPhosphoSitePlus22135298
202IQKGLQASRSDIKLFcurated25627689
443EKCLPPPSIRVVVTVdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18491316; 16381945; 23193290; 18988627; 22135298; 19366988;
Sequence
(Fasta)		MATATEQWVL VEMVQALYEA PAYHLILEGI LILWIIRLLF SKTYKLQERS DLTVKEKEEL 60
IEEWQPEPLV PPVPKDHPAL NYNIVSGPPS HKTVVNGKEC INFASFNFLG LLDNPRVKAA 120
ALASLKKYGV GTCGPRGFYG TFDVHLDLED RLAKFMKTEE AIIYSYGFAT IASAIPAYSK 180
RGDIVFVDRA ACFAIQKGLQ ASRSDIKLFK HNDMADLERL LKEQEIEDQK NPRKARVTRR 240
FIVVEGLYMN TGTICPLPEL VKLKYKYKAR IFLEESLSFG VLGEHGRGVT EHYGINIDDI 300
DLISANMENA LASIGGFCCG RSFVIDHQRL SGQGYCFSAS LPPLLAAAAI EALNIMEENP 360
GIFAVLKEKC GQIHKALQGI SGLKVVGESL SPAFHLQLEE STGSREQDVR LLQEIVDQCM 420
NRSIALTQAR YLEKEEKCLP PPSIRVVVTV EQTEEELERA ASTIKEVAQA VLL 474
Keyword

KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0663--Pyridoxal phosphate
KW-1185--Reference proteome
KW-0746--Sphingolipid metabolism
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR004839--Aminotransferase_I/II
IPR015424--PyrdxlP-dep_Trfase
IPR015421--PyrdxlP-dep_Trfase_major_sub1
IPR015422--PyrdxlP-dep_Trfase_major_sub2
PROSITE
Pfam

PF00155--Aminotran_1_2
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0017059--C:serine C-palmitoyltransferase complex
GO:0035339--C:SPOTS complex
GO:0030170--F:pyridoxal phosphate binding
GO:0004758--F:serine C-palmitoyltransferase activity
GO:0046513--P:ceramide biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0046511--P:sphinganine biosynthetic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process
GO:0006686--P:sphingomyelin biosynthetic process
GO:0046512--P:sphingosine biosynthetic process