dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000915
Uniprot Accession O15265; ATX7_HUMAN; B4E207; E9PHP9; O75328; O75329; Q9Y6P8;
Genbank Protein ID NP_000324.1; NP_001121621.2; NP_001170858.1;
Genbank Nucleotide ID NM_000333.3; NM_001128149.2; NM_001177387.1;
Protein Name Ataxin-7
Protein Synonyms/Alias Spinocerebellar ataxia type 7 protein;
Gene Name ATXN7
Gene Synonyms/Alias SCA7;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.
Phosphorylation Sites
 dbPAF PTMs: 41 (View all)
PositionPeptidesSourceReferences ( PMIDs )
69DGGPGAASTSAAAMAPhosphoSitePlus22135298
70GGPGAASTSAAAMATPhosphoSitePlus22135298
86GERRPLPSPEVMLGQPhosphoSitePlus;curated22135298; 23898821
115DGTELDESFKEFGKNPhosphoSitePlus;curated22135298; 25627689
206SASGSNRSSSGGVLScurated25627689
207ASGSNRSSSGGVLSAcurated25627689
215SGGVLSASSSSSKLLcurated25627689
216GGVLSASSSSSKLLKPhosphoSitePlus;curated22135298; 25627689
217GVLSASSSSSKLLKScurated25627689
218VLSASSSSSKLLKSPcurated25627689
219LSASSSSSKLLKSPKPhosphoSitePlus;curated22135298; 25627689
302IPKPTLPSPGQILNGPhosphoSitePlus;curated22135298; 25627689
337KFLNKRLSEREFDPDcurated23898821
361TKKPCTRSLTCKTHSPhosphoSitePlus22135298
491TEPASRLSSEEGEGDcurated25850435; 20873877
492EPASRLSSEEGEGDDPhosphoSitePlus;curated22135298; 25850435; 25627689; 20873877
568KKIPPVPSTTSPISTcurated25003641
570IPPVPSTTSPISTRIcurated25627689
571PPVPSTTSPISTRIPcurated25627689; 23186163
612LLSSTCISPNSKSVPcurated26074081
Sequence
(Fasta)		MSERAADDVR GEPRRAAAAA GGAAAAAARQ QQQQQQQQQP PPPQPQRQQH PPPPPRRTRP 60
EDGGPGAAST SAAAMATVGE RRPLPSPEVM LGQSWNLWVE ASKLPGKDGT ELDESFKEFG 120
KNREVMGLCR EDMPIFGFCP AHDDFYLVVC NDCNQVVKPQ AFQSHYERRH SSSSKPPLAV 180
PPTSVFSFFP SLSKSKGGSA SGSNRSSSGG VLSASSSSSK LLKSPKEKLQ LRGNTRPMHP 240
IQQSRVPHGR IMTPSVKVEK IHPKMDGTLL KSAVGPTCPA TVSSLVKPGL NCPSIPKPTL 300
PSPGQILNGK GLPAPPTLEK KPEDNSNNRK FLNKRLSERE FDPDIHCGVI DLDTKKPCTR 360
SLTCKTHSLT QRRAVQGRRK RFDVLLAEHK NKTREKELIR HPDSQQPPQP LRDPHPAPPR 420
TSQEPHQNPH GVIPSESKPF VASKPKPHTP SLPRPPGCPA QQGGSAPIDP PPVHESPHPP 480
LPATEPASRL SSEEGEGDDK EESVEKLDCH YSGHHPQPAS FCTFGSRQIG RGYYVFDSRW 540
NRLRCALNLM VEKHLNAQLW KKIPPVPSTT SPISTRIPHR TNSVPTSQCG VSYLAAATVS 600
TSPVLLSSTC ISPNSKSVPA HGTTLNAQPA ASGAMDPVCS MQSRQVSSSS SSPSTPSGLS 660
SVPSSPMSRK PQKLKSSKSL RPKESSGNST NCQNASSSTS GGSGKKRKNS SPLLVHSSSS 720
SSSSSSSSHS MESFRKNCVA HSGPPYPSTV TSSHSIGLNC VTNKANAVNV RHDQSGRGPP 780
TGSPAESIKR MSVMVNSSDS TLSLGPFIHQ SNELPVNSHG SFSHSHTPLD KLIGKKRKCS 840
PSSSSINNSS SKPTKVAKVP AVNNVHMKHT GTIPGAQGLM NSSLLHQPKA RP 893
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-1017--Isopeptide bond
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0950--Spinocerebellar ataxia
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0818--Triplet repeat expansion
KW-0832--Ubl conjugation
Interpro

IPR030706--ATXN7
IPR013243--SCA7_dom
IPR015880--Znf_C2H2-like
PROSITE

PS51505--SCA7
Pfam

PF08313--SCA7
Gene Ontology

GO:0005737--C:cytoplasm
GO:0015630--C:microtubule cytoskeleton
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030914--C:STAGA complex
GO:0003682--F:chromatin binding
GO:0006325--P:chromatin organization
GO:0016578--P:histone deubiquitination
GO:0000226--P:microtubule cytoskeleton organization
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0042326--P:negative regulation of phosphorylation
GO:0006997--P:nucleus organization
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0007601--P:visual perception