dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000901
Uniprot Accession O15232; MATN3_HUMAN; B2CPU0; Q4ZG02;
Genbank Protein ID NP_002372.1;
Genbank Nucleotide ID NM_002381.4;
Protein Name Matrilin-3
Protein Synonyms/Alias
Gene Name MATN3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
65DGAPASGTSEPGRARPhosphoSitePlus22135298
93FIIDSSRSVRPLEFTPhosphoSitePlus;curated22135298; 22817900
112FVSRIIDTLDIGPADPhosphoSitePlus22135298
120LDIGPADTRVAVVNYPhosphoSitePlus22135298
154KQAVGRITPLSTGTMPhosphoSitePlus22135298
175TAMDEAFTVEAGAREPhosphoSitePlus22135298
184EAGAREPSSNIPKVAPhosphoSitePlus22135298
295HCECSQGYTLNADKKdbPTM 3.0;PhosphoSitePlus;curated17053785; 16381945; 23193290; 22135298; 22817900
407GCQHICVSDGAASYHPhosphoSitePlus22135298
441EEARRLVSTEDACGCPhosphoSitePlus22135298
459LAFQDKVSSYLQRLNPhosphoSitePlus22135298
Sequence
(Fasta)		MPRPAPARRL PGLLLLLWPL LLLPSAAPDP VARPGFRRLE TRGPGGSPGR RPSPAAPDGA 60
PASGTSEPGR ARGAGVCKSR PLDLVFIIDS SRSVRPLEFT KVKTFVSRII DTLDIGPADT 120
RVAVVNYAST VKIEFQLQAY TDKQSLKQAV GRITPLSTGT MSGLAIQTAM DEAFTVEAGA 180
REPSSNIPKV AIIVTDGRPQ DQVNEVAARA QASGIELYAV GVDRADMASL KMMASEPLEE 240
HVFYVETYGV IEKLSSRFQE TFCALDPCVL GTHQCQHVCI SDGEGKHHCE CSQGYTLNAD 300
KKTCSALDRC ALNTHGCEHI CVNDRSGSYH CECYEGYTLN EDRKTCSAQD KCALGTHGCQ 360
HICVNDRTGS HHCECYEGYT LNADKKTCSV RDKCALGSHG CQHICVSDGA ASYHCDCYPG 420
YTLNEDKKTC SATEEARRLV STEDACGCEA TLAFQDKVSS YLQRLNTKLD DILEKLKINE 480
YGQIHR 487
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0242--Dwarfism
KW-0245--EGF-like domain
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR009030--Growth_fac_rcpt_N_dom
IPR030765--Matrilin-3/4
IPR019466--Matrilin_coiled-coil_trimer
IPR002035--VWF_A
PROSITE

PS01186--EGF_2
PS50026--EGF_3
PS50234--VWFA
Pfam

PF07645--EGF_CA
PF10393--Matrilin_ccoil
PF00092--VWA
Gene Ontology

GO:0005576--C:extracellular region
GO:0005578--C:proteinaceous extracellular matrix
GO:0005509--F:calcium ion binding
GO:0005201--F:extracellular matrix structural constituent
GO:0030198--P:extracellular matrix organization
GO:0001501--P:skeletal system development