dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000898
Uniprot Accession O15229; KMO_HUMAN; A2A2U8; A2A2U9; A2A2V0; Q5SY07; Q5SY08; Q5SY09;
Genbank Protein ID NP_003670.2;
Genbank Nucleotide ID NM_003679.4;
Protein Name Kynurenine 3-monooxygenase
Protein Synonyms/Alias Kynurenine 3-hydroxylase;
Gene Name KMO
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
95HSLSGKKSAIPYGTKcurated25262027
99GKKSAIPYGTKSQYIdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900; 25262027
101KSAIPYGTKSQYILScurated25262027
105PYGTKSQYILSVSREdbPTM 3.0;PhosphoSitePlus;curated18083107; 21253578; 16381945; 23193290; 22135298; 22817900;
108TKSQYILSVSRENLNcurated25262027
110SQYILSVSRENLNKDcurated26074081; 25262027
175GAYSTVRSHLMKKPRPhosphoSitePlus22135298
206IPPKNGDYAMEPNYLdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MDSSVIQRKK VAVIGGGLVG SLQACFLAKR NFQIDVYEAR EDTRVATFTR GRSINLALSH 60
RGRQALKAVG LEDQIVSQGI PMRARMIHSL SGKKSAIPYG TKSQYILSVS RENLNKDLLT 120
AAEKYPNVKM HFNHRLLKCN PEEGMITVLG SDKVPKDVTC DLIVGCDGAY STVRSHLMKK 180
PRFDYSQQYI PHGYMELTIP PKNGDYAMEP NYLHIWPRNT FMMIALPNMN KSFTCTLFMP 240
FEEFEKLLTS NDVVDFFQKY FPDAIPLIGE KLLVQDFFLL PAQPMISVKC SSFHFKSHCV 300
LLGDAAHAIV PFFGQGMNAG FEDCLVFDEL MDKFSNDLSL CLPVFSRLRI PDDHAISDLS 360
MYNYIEMRAH VNSSWFIFQK NMERFLHAIM PSTFIPLYTM VTFSRIRYHE AVQRWHWQKK 420
VINKGLFFLG SLIAISSTYL LIHYMSPRSF LRLRRPWNWI AHFRNTTCFP AKAVDSLEQI 480
SNLISR 487
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0274--FAD
KW-0285--Flavoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0503--Monooxygenase
KW-0521--NADP
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-0662--Pyridine nucleotide biosynthesis
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR002938--FAD-bd
IPR023753--FAD/NAD-binding_dom
IPR027545--Kynurenine_monooxygenase
PROSITE
Pfam

PF01494--FAD_binding_3
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0071949--F:FAD binding
GO:0050660--F:flavin adenine dinucleotide binding
GO:0004502--F:kynurenine 3-monooxygenase activity
GO:0016174--F:NAD(P)H oxidase activity
GO:0034354--P:'de novo' NAD biosynthetic process from tryptophan
GO:0043420--P:anthranilate metabolic process
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0070189--P:kynurenine metabolic process
GO:0019674--P:NAD metabolic process
GO:0019805--P:quinolinate biosynthetic process
GO:0009651--P:response to salt stress
GO:0044550--P:secondary metabolite biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0006569--P:tryptophan catabolic process
GO:0019441--P:tryptophan catabolic process to kynurenine