dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000893
Uniprot Accession O15212; PFD6_HUMAN;
Genbank Protein ID NP_001172110.1; NP_001252524.1; NP_001252525.1; NP_055075.1;
Genbank Nucleotide ID NM_001185181.2; NM_001265595.1; NM_001265596.1; NM_014260.3;
Protein Name Prefoldin subunit 6
Protein Synonyms/Alias Protein Ke2;
Gene Name PFDN6
Gene Synonyms/Alias HKE2;PFD6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
16LQGEVEKYQQLQKDLPhosphoSitePlus22135298
82TVGKRLDYITAEIKRPhosphoSitePlus22135298
84GKRLDYITAEIKRYEPHOSIDA;PhosphoSitePlus21081558; 22135298
90ITAEIKRYESQLRDLdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
92AEIKRYESQLRDLERcurated23898821
Sequence
(Fasta)		MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL 60
GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ SEQQRETLAQ LQQEFQRAQA 120
AKAGAPGKA
Keyword

KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR002777--PFD_beta-like
IPR009053--Prefoldin
PROSITE
Pfam

PF01920--Prefoldin_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016272--C:prefoldin complex
GO:0051087--F:chaperone binding
GO:0051082--F:unfolded protein binding
GO:0051084--P:'de novo' posttranslational protein folding
GO:0044267--P:cellular protein metabolic process
GO:0051131--P:chaperone-mediated protein complex assembly
GO:0006457--P:protein folding