dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000892
Uniprot Accession O15211; RGL2_HUMAN; B4DG72; Q5STK0; Q9Y3F3;
Genbank Protein ID NP_001230667.1; NP_004752.1;
Genbank Nucleotide ID NM_001243738.1; NM_004761.4;
Protein Name Ral guanine nucleotide dissociation stimulator-like 2
Protein Synonyms/Alias
Gene Name RGL2
Gene Synonyms/Alias RAB2L;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
12PLRLLLDTSPPGGVVcurated25850435
13LRLLLDTSPPGGVVLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18220336; 16381945; 23193290; 16964243; 19276368; 20068231;
21PPGGVVLSSFRSRDPdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
22PGGVVLSSFRSRDPEdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
25VVLSSFRSRDPEEGGdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
409VQEVKLQSPLEPHSKPhosphoSitePlus;curated22135298; 25627689; 23917254; 22798277
431RGGGVVPYLGTFLKDPhosphoSitePlus22135298
434GVVPYLGTFLKDLVMdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 22817900
446LVMLDAASKDELENGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 22817900
454KDELENGYINFDKRRPhosphoSitePlus22135298
562GGDEAPTTPAPLLTRcurated25850435
578AQHMKWPSVSSLDSAPhosphoSitePlus22135298
607HLSPPASSPRPSRGHPhosphoSitePlus22135298
617PSRGHRRSASCGSPLPhosphoSitePlus;curated22135298; 23898821; 23090842; 22817900; 25262027
619RGHRRSASCGSPLSGPhosphoSitePlus;curated22135298; 23898821; 25262027
622RRSASCGSPLSGGAEcurated23090842; 23186163
736LLRQRRRSSTATPGVPhosphoSitePlus22135298
737LRQRRRSSTATPGVTPhosphoSitePlus22135298
740RRRSSTATPGVTSGPPhosphoSitePlus22135298
744STATPGVTSGPSASGPhosphoSitePlus22135298
Sequence
(Fasta)		MLPRPLRLLL DTSPPGGVVL SSFRSRDPEE GGGPGGLVVG GGQEEEEEEE EEAPVSVWDE 60
EEDGAVFTVT SRQYRPLDPL VPMPPPRSSR RLRAGTLEAL VRHLLDTRTS GTDVSFMSAF 120
LATHRAFTST PALLGLMADR LEALESHPTD ELERTTEVAI SVLSTWLASH PEDFGSEAKG 180
QLDRLESFLL QTGYAAGKGV GGGSADLIRN LRSRVDPQAP DLPKPLALPG DPPADPTDVL 240
VFLADHLAEQ LTLLDAELFL NLIPSQCLGG LWGHRDRPGH SHLCPSVRAT VTQFNKVAGA 300
VVSSVLGATS TGEGPGEVTI RPLRPPQRAR LLEKWIRVAE ECRLLRNFSS VYAVVSALQS 360
SPIHRLRAAW GEATRDSLRV FSSLCQIFSE EDNYSQSREL LVQEVKLQSP LEPHSKKAPR 420
SGSRGGGVVP YLGTFLKDLV MLDAASKDEL ENGYINFDKR RKEFAVLSEL RRLQNECRGY 480
NLQPDHDIQR WLQGLRPLTE AQSHRVSCEV EPPGSSDPPA PRVLRPTLVI SQWTEVLGSV 540
GVPTPLVSCD RPSTGGDEAP TTPAPLLTRL AQHMKWPSVS SLDSALESSP SLHSPADPSH 600
LSPPASSPRP SRGHRRSASC GSPLSGGAEE ASGGTGYGGE GSGPGASDCR IIRVQMELGE 660
DGSVYKSILV TSQDKAPSVI SRVLKKNNRD SAVASEYELV QLLPGERELT IPASANVFYA 720
MDGASHDFLL RQRRRSSTAT PGVTSGPSAS GTPPSEGGGG SFPRIKATGR KIARALF 778
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR000159--RA_dom
IPR000651--Ras-like_Gua-exchang_fac_N
IPR019804--Ras_G-nucl-exch_fac_CS
IPR023578--Ras_GEF_dom
IPR001895--RASGEF_cat_dom
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50200--RA
PS00720--RASGEF
PS50009--RASGEF_CAT
PS50212--RASGEF_NTER
Pfam

PF00788--RA
PF00617--RasGEF
PF00618--RasGEF_N
Gene Ontology

GO:0005622--C:intracellular
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0043547--P:positive regulation of GTPase activity
GO:0007265--P:Ras protein signal transduction