dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000888
Uniprot Accession O15198; SMAD9_HUMAN; A2A2Y6; O14989; Q5TBA1;
Genbank Protein ID NP_001120689.1; NP_005896.1;
Genbank Nucleotide ID NM_001127217.2; NM_005905.5;
Protein Name Mothers against decapentaplegic homolog 9
Protein Synonyms/Alias
Gene Name SMAD9
Gene Synonyms/Alias MADH6;MADH9;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
15SSLFSFTSPAVKRLLcurated20068231
40WAEKAVDSLVKKLKKPhosphoSitePlus22135298
82LDGRLQVSHRKGLPHPhosphoSitePlus22135298
92KGLPHVIYCRVWRWPPhosphoSitePlus22135298
136YHYRRVETPVLPPVLPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25850435
317RFCLGLLSNVNRNSTPhosphoSitePlus22135298
323LSNVNRNSTIENTRRcurated22798277
324SNVNRNSTIENTRRHPhosphoSitePlus22135298
454QWLDKVLTQMGSPHNcurated25627689
458KVLTQMGSPHNPISSPhosphoSitePlus;curated22135298; 25627689
464GSPHNPISSVS----dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 10085121; 9748228; 9136927; 18
465SPHNPISSVS-----dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18669648; 19664995; 20068231;
467HNPISSVS-------dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18669648; 20068231; 20085741;
Sequence
(Fasta)		MHSTTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMDELERALS 60
CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPL ECCEFPFGSK 120
QKEVCINPYH YRRVETPVLP PVLVPRHSEY NPQLSLLAKF RSASLHSEPL MPHNATYPDS 180
FQQPPCSALP PSPSHAFSQS PCTASYPHSP GSPSEPESPY QHSVDTPPLP YHATEASETQ 240
SGQPVDATAD RHVVLSIPNG DFRPVCYEEP QHWCSVAYYE LNNRVGETFQ ASSRSVLIDG 300
FTDPSNNRNR FCLGLLSNVN RNSTIENTRR HIGKGVHLYY VGGEVYAECV SDSSIFVQSR 360
NCNYQHGFHP ATVCKIPSGC SLKVFNNQLF AQLLAQSVHH GFEVVYELTK MCTIRMSFVK 420
GWGAEYHRQD VTSTPCWIEI HLHGPLQWLD KVLTQMGSPH NPISSVS 468
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR013790--Dwarfin
IPR003619--MAD_homology1_Dwarfin-type
IPR013019--MAD_homology_MH1
IPR017855--SMAD_dom-like
IPR001132--SMAD_dom_Dwarfin-type
IPR008984--SMAD_FHA_domain
PROSITE

PS51075--MH1
PS51076--MH2
Pfam

PF03165--MH1
PF03166--MH2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0071141--C:SMAD protein complex
GO:0005667--C:transcription factor complex
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0030618--F:transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030509--P:BMP signaling pathway
GO:0060348--P:bone development
GO:0051216--P:cartilage development
GO:0071773--P:cellular response to BMP stimulus
GO:0071407--P:cellular response to organic cyclic compound
GO:0030902--P:hindbrain development
GO:0035556--P:intracellular signal transduction
GO:0030901--P:midbrain development
GO:1901522--P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0006468--P:protein phosphorylation
GO:0060395--P:SMAD protein signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0001657--P:ureteric bud development