dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000887
Uniprot Accession O15197; EPHB6_HUMAN; A4D2I7; A8CDT5; D3DXD3; Q2TB23; Q2TB24;
Genbank Protein ID NP_001267724.2; NP_004436.4;
Genbank Nucleotide ID NM_001280795.2; NM_004445.5;
Protein Name Ephrin type-B receptor 6
Protein Synonyms/Alias HEP;Tyrosine-protein kinase-defective receptor EPH-6;
Gene Name EPHB6
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
168DESFPSSSSSSSSSSPhosphoSitePlus22135298
169ESFPSSSSSSSSSSSPhosphoSitePlus22135298
170SFPSSSSSSSSSSSAPhosphoSitePlus22135298
171FPSSSSSSSSSSSAAPhosphoSitePlus22135298
635YTEQLQQYSSPGLGVPhosphoSitePlus;curated22135298; 22817900
644SPGLGVKYYIDPSTYPhosphoSitePlus;curated22135298; 22817900
645PGLGVKYYIDPSTYEdbPTM 3.0;PhosphoSitePlus;curated11713248; 16381945; 23193290; 22135298; 22817900
651YYIDPSTYEDPCQAIdbPTM 3.0;PhosphoSitePlus;curated11713248; 16381945; 23193290; 22135298; 22817900
669AREVDPAYIKIEEVIPhosphoSitePlus22135298
Sequence
(Fasta)		MATEGAAQLG NRVAGMVCSL WVLLLVSSVL ALEEVLLDTT GETSEIGWLT YPPGGWDEVS 60
VLDDQRRLTR TFEACHVAGA PPGTGQDNWL QTHFVERRGA QRAHIRLHFS VRACSSLGVS 120
GGTCRETFTL YYRQAEEPDS PDSVSSWHLK RWTKVDTIAA DESFPSSSSS SSSSSSAAWA 180
VGPHGAGQRA GLQLNVKERS FGPLTQRGFY VAFQDTGACL ALVAVRLFSY TCPAVLRSFA 240
SFPETQASGA GGASLVAAVG TCVAHAEPEE DGVGGQAGGS PPRLHCNGEG KWMVAVGGCR 300
CQPGYQPARG DKACQACPRG LYKSSAGNAP CSPCPARSHA PNPAAPVCPC LEGFYRASSD 360
PPEAPCTGPP SAPQELWFEV QGSALMLHWR LPRELGGRGD LLFNVVCKEC EGRQEPASGG 420
GGTCHRCRDE VHFDPRQRGL TESRVLVGGL RAHVPYILEV QAVNGVSELS PDPPQAAAIN 480
VSTSHEVPSA VPVVHQVSRA SNSITVSWPQ PDQTNGNILD YQLRYYDQAE DESHSFTLTS 540
ETNTATVTQL SPGHIYGFQV RARTAAGHGP YGGKVYFQTL PQGELSSQLP ERLSLVIGSI 600
LGALAFLLLA AITVLAVVFQ RKRRGTGYTE QLQQYSSPGL GVKYYIDPST YEDPCQAIRE 660
LAREVDPAYI KIEEVIGTGS FGEVRQGRLQ PRGRREQTVA IQALWAGGAE SLQMTFLGRA 720
AVLGQFQHPN ILRLEGVVTK SRPLMVLTEF MELGPLDSFL RQREGQFSSL QLVAMQRGVA 780
AAMQYLSSFA FVHRSLSAHS VLVNSHLVCK VARLGHSPQG PSCLLRWAAP EVIAHGKHTT 840
SSDVWSFGIL MWEVMSYGER PYWDMSEQEV LNAIEQEFRL PPPPGCPPGL HLLMLDTWQK 900
DRARRPHFDQ LVAAFDKMIR KPDTLQAGGD PGERPSQALL TPVALDFPCL DSPQAWLSAI 960
GLECYQDNFS KFGLCTFSDV AQLSLEDLPA LGITLAGHQK KLLHHIQLLQ QHLRQQGSVE 1020
V 1022
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR027936--Eph_TM
IPR001090--Ephrin_rcpt_lig-bd_dom
IPR003961--FN3_dom
IPR008979--Galactose-bd-like
IPR009030--Growth_fac_rcpt_N_dom
IPR013783--Ig-like_fold
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001660--SAM
IPR013761--SAM/pointed
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR011641--Tyr-kin_ephrin_A/B_rcpt-like
IPR016257--Tyr_kinase_ephrin_rcpt
IPR001426--Tyr_kinase_rcpt_V_CS
PROSITE

PS51550--EPH_LBD
PS50853--FN3
PS50011--PROTEIN_KINASE_DOM
PS00790--RECEPTOR_TYR_KIN_V_1
PS00791--RECEPTOR_TYR_KIN_V_2
PS50105--SAM_DOMAIN
Pfam

PF14575--EphA2_TM
PF01404--Ephrin_lbd
PF00041--fn3
PF07699--GCC2_GCC3
PF07714--Pkinase_Tyr
PF07647--SAM_2
Gene Ontology

GO:0005829--C:cytosol
GO:0005576--C:extracellular region
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0005003--F:ephrin receptor activity
GO:0004872--F:receptor activity
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway