dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000885 |
| Uniprot Accession | O15194; CTDSL_HUMAN; Q3ZTU0; Q70KI4; Q7Z5Q2; |
| Genbank Protein ID | NP_001008393.1; NP_005799.2; |
| Genbank Nucleotide ID | NM_001008392.1; NM_005808.2; |
| Protein Name | CTD small phosphatase-like protein |
| Protein Synonyms/Alias | |
| Gene Name | CTDSPL |
| Gene Synonyms/Alias | C3orf8;NIF1;NIFL;SCP3;YA22; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MDGPAIITQV TNPKEDEGRL PGAGEKASQC NVSLKKQRSR SILSSFFCCF RDYNVEAPPP 60 SSPSVLPPLV EENGGLQKGD QRQVIPIPSP PAKYLLPEVT VLDYGKKCVV IDLDETLVHS 120 SFKPISNADF IVPVEIDGTI HQVYVLKRPH VDEFLQRMGQ LFECVLFTAS LAKYADPVAD 180 LLDRWGVFRA RLFRESCVFH RGNYVKDLSR LGRELSKVII VDNSPASYIF HPENAVPVQS 240 WFDDMTDTEL LDLIPFFEGL SREDDVYSML HRLCNR 277 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR011948--Dullard_phosphatase |
| PROSITE | PS50969--FCP1 |
| Pfam | PF03031--NIF |
| Gene Ontology | GO:0070062--C:extracellular exosome |