dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000883
Uniprot Accession O15178; BRAC_HUMAN; E7ERD6; Q4KMP4;
Genbank Protein ID NP_001257413.1; NP_003172.1; XP_011534383.1;
Genbank Nucleotide ID NM_001270484.1; NM_003181.3; XM_011536081.1;
Protein Name Brachyury protein
Protein Synonyms/Alias Protein T;
Gene Name T
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
65LTNEMIVTKNGRRMFPhosphoSitePlus22135298
149SFSKVKLTNKLNGGGPhosphoSitePlus22135298
162GGQIMLNSLHKYEPRPhosphoSitePlus22135298
431IASWTPVSPPSM---dbPTM 3.0;HPRD 9;PhosphoSitePlus19415658; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)		MSSPGTESAG KSLQYRVDHL LSAVENELQA GSEKGDPTER ELRVGLEESE LWLRFKELTN 60
EMIVTKNGRR MFPVLKVNVS GLDPNAMYSF LLDFVAADNH RWKYVNGEWV PGGKPEPQAP 120
SCVYIHPDSP NFGAHWMKAP VSFSKVKLTN KLNGGGQIML NSLHKYEPRI HIVRVGGPQR 180
MITSHCFPET QFIAVTAYQN EEITALKIKY NPFAKAFLDA KERSDHKEMM EEPGDSQQPG 240
YSQWGWLLPG TSTLCPPANP HPQFGGALSL PSTHSCDRYP TLRSHRSSPY PSPYAHRNNS 300
PTYSDNSPAC LSMLQSHDNW SSLGMPAHPS MLPVSHNASP PTSSSQYPSL WSVSNGAVTP 360
GSQAAAVSNG LGAQFFRGSP AHYTPLTHPV SAPSSSGSPL YEGAAAATDI VDSQYDAAAQ 420
GRLIASWTPV SPPSM 436
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR008967--p53-like_TF_DNA-bd
IPR002070--TF_Brachyury
IPR001699--TF_T-box
IPR018186--TF_T-box_CS
PROSITE

PS01283--TBOX_1
PS01264--TBOX_2
PS50252--TBOX_3
Pfam

PF00907--T-box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0030509--P:BMP signaling pathway
GO:0060349--P:bone morphogenesis
GO:0060070--P:canonical Wnt signaling pathway
GO:0071300--P:cellular response to retinoic acid
GO:0061371--P:determination of heart left/right asymmetry
GO:0048706--P:embryonic skeletal system development
GO:0003007--P:heart morphogenesis
GO:0007498--P:mesoderm development
GO:0007509--P:mesoderm migration involved in gastrulation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001839--P:neural plate morphogenesis
GO:0001843--P:neural tube closure
GO:0014028--P:notochord formation
GO:0007341--P:penetration of zona pellucida
GO:0008284--P:positive regulation of cell proliferation
GO:0003257--P:positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0036342--P:post-anal tail morphogenesis
GO:0090009--P:primitive streak formation
GO:0007165--P:signal transduction
GO:0023019--P:signal transduction involved in regulation of gene expression
GO:0060395--P:SMAD protein signal transduction
GO:0001756--P:somitogenesis
GO:0006351--P:transcription, DNA-templated
GO:0001570--P:vasculogenesis