dbPAF Protein Information
| Tag | Content | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000879 | ||||||||||||||||
| Uniprot Accession | O15165; LRAD4_HUMAN; B3KNT9; E9PAY9; K7EN38; O15166; O15167; O15168; Q5U646; Q6NXP3; | ||||||||||||||||
| Genbank Protein ID | NP_001003674.1; NP_001003675.1; NP_001263178.1; NP_001263180.1; NP_852146.1; NP_852147.1; XP_005258197.1; XP_006722416.1; XP_006722417.1; XP_011524040.1; XP_011524041.1; | ||||||||||||||||
| Genbank Nucleotide ID | NM_001003674.3; NM_001003675.3; NM_001276249.1; NM_001276251.1; NM_181481.4; NM_181482.4; XM_005258140.1; XM_006722353.1; XM_006722354.1; XM_011525738.1; XM_011525739.1; | ||||||||||||||||
| Protein Name | Low-density lipoprotein receptor class A domain-containing protein 4 | ||||||||||||||||
| Protein Synonyms/Alias | |||||||||||||||||
| Gene Name | LDLRAD4 | ||||||||||||||||
| Gene Synonyms/Alias | C18orf1; | ||||||||||||||||
| Organism | Homo sapiens(Human) | ||||||||||||||||
| NCBI Taxa ID | 9606 | ||||||||||||||||
| Functional Description (View all) |
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. | ||||||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 3
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| Sequence (Fasta) | MPEAGFQATN AFTECKFTCT SGKCLYLGSL VCNQQNDCGD NSDEENCLLV TEHPPPGIFN 60 SELEFAQIII IVVVVTVMVV VIVCLLNHYK VSTRSFINRP NQSRRREDGL PQEGCLWPSD 120 SAAPRLGASE IMHAPRSRDR FTAPSFIQRD RFSRFQPTYP YVQHEIDLPP TISLSDGEEP 180 PPYQGPCTLQ LRDPEQQMEL NRESVRAPPN RTIFDSDLID IAMYSGGPCP PSSNSGISAS 240 TCSSNGRMEG PPPTYSEVMG HHPGASFLHH QRSNAHRGSR LQFQQNNAES TIVPIKGKDR 300 KPGNLV 307 |
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| Keyword | KW-0025--Alternative splicing |
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| Interpro | |||||||||||||||||
| PROSITE | |||||||||||||||||
| Pfam | PF00057--Ldl_recept_a |
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| Gene Ontology | GO:0031901--C:early endosome membrane |