dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000876
Uniprot Accession O15160; RPAC1_HUMAN; O75395; Q5JTE3;
Genbank Protein ID NP_976035.1; XP_005249548.1;
Genbank Nucleotide ID NM_203290.2; XM_005249491.1;
Protein Name DNA-directed RNA polymerases I and III subunit RPAC1
Protein Synonyms/Alias
Gene Name POLR1C
Gene Synonyms/Alias POLR1E;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
4----MAASQAVEEMRdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 25627689; 23186163;
33TTDFPGNYSGYDDAWdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated15592455; 16381945; 23193290; 18988627; 19060867; 22135298;
34TDFPGNYSGYDDAWDPhosphoSitePlus;curated22135298; 25627689
36FPGNYSGYDDAWDQDPhosphoSitePlus;curated22135298; 22817900
124ADPRLFEYRNQGDEEdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
157PHAAKDSSDPNELYVPhosphoSitePlus;curated22135298; 25627689
226GKDHAKFSPVATASYdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
254GEAAEELSRCFSPGVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
258EELSRCFSPGVIEVQPhosphoSitePlus;curated22135298; 25627689
282VANPRLDTFSREIFRdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900; 23186163
284NPRLDTFSREIFRNEdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS 60
LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR 120
LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN 180
QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT 240
LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA 300
RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD 347
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0240--DNA-directed RNA polymerase
KW-1026--Leukodystrophy
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
Interpro

IPR001514--DNA-dir_RNA_pol_30-40kDasu_CS
IPR011262--DNA-dir_RNA_pol_insert
IPR011263--DNA-dir_RNA_pol_RpoA/D/Rpb3
IPR009025--RBP11-like_dimer
PROSITE

PS00446--RNA_POL_D_30KD
Pfam

PF01000--RNA_pol_A_bac
PF01193--RNA_pol_L
Gene Ontology

GO:0005829--C:cytosol
GO:0005736--C:DNA-directed RNA polymerase I complex
GO:0005666--C:DNA-directed RNA polymerase III complex
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0003899--F:DNA-directed RNA polymerase activity
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0032481--P:positive regulation of type I interferon production
GO:0040029--P:regulation of gene expression, epigenetic
GO:0006363--P:termination of RNA polymerase I transcription
GO:0006386--P:termination of RNA polymerase III transcription
GO:0006362--P:transcription elongation from RNA polymerase I promoter
GO:0006385--P:transcription elongation from RNA polymerase III promoter
GO:0006360--P:transcription from RNA polymerase I promoter
GO:0006383--P:transcription from RNA polymerase III promoter
GO:0006361--P:transcription initiation from RNA polymerase I promoter