dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000875
Uniprot Accession O15156; ZBT7B_HUMAN; B4E3K5; D3DV83; J3KQQ3; Q68DR2; Q96EP2;
Genbank Protein ID NP_001239335.1; NP_001243384.1; XP_006711412.2; XP_006711416.1; XP_006711417.1; XP_006711419.1; XP_006711420.1; XP_006711421.1; XP_006711422.1; XP_011507900.1; XP_011507901.1;
Genbank Nucleotide ID NM_001252406.2; NM_001256455.1; XM_006711349.2; XM_006711353.1; XM_006711354.1; XM_006711356.2; XM_006711357.1; XM_006711358.1; XM_006711359.1; XM_011509598.1; XM_011509599.1;
Protein Name Zinc finger and BTB domain-containing protein 7B
Protein Synonyms/Alias Krueppel-related zinc finger protein cKrox;hcKrox;T-helper-inducing POZ/Krueppel-like factor;Zinc finger and BTB domain-containing protein 15;Zinc finger protein 67 homolog;Zfp-67;Zinc finger protein 857B;Zinc finger protein Th-POK;
Gene Name ZBTB7B
Gene Synonyms/Alias ZBTB15;ZFP67;ZNF857B;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
3-----MGSPEDDLIGdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 23663014
150GSGLEAPSPDEDDCEPhosphoSitePlus;UniProt;curated22135298; 24275569; 20873877
180GVPNGEDSPPQVPLPdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25849741
367KLPRHMRTHTGEKPFPhosphoSitePlus22135298
369PRHMRTHTGEKPFACdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 19060867; 22135298;
471KDDAPPHYPPPSTAAdbPTM 3.0;PhosphoSitePlus21253578; 16381945; 23193290; 22135298
480PPSTAAASPAGLDLSPhosphoSitePlus;curated22135298; 25627689
487SPAGLDLSNGHLDTFcurated23090842
528DEEEGAPTTPQAEGAdbPTM 3.0;HPRD 9;curated18452278; 20068231; 16381945; 23193290; 18988627
529EEEGAPTTPQAEGAMdbPTM 3.0;HPRD 9;curated18452278; 16381945; 23193290; 18988627; 20068231
Sequence
(Fasta)		MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 60
KLFTEGGGGA VMGAGGSGTA TGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 120
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT ASGVPNGEDS 180
PPQVPLPPPP PPPPRPVARR SRKPRKAFLQ TKGARANHLV PEVPTVPAHP LTYEEEEVAG 240
RVGSSGGSGP GDSYSPPTGT ASPPEGPQSY EPYEGEEEEE ELVYPPAYGL AQGGGPPLSP 300
EELGSDEDAI DPDLMAYLSS LHQDNLAPGL DSQDKLVRKR RSQMPQECPV CHKIIHGAGK 360
LPRHMRTHTG EKPFACEVCG VRFTRNDKLK IHMRKHTGER PYSCPHCPAR FLHSYDLKNH 420
MHLHTGDRPY ECHLCHKAFA KEDHLQRHLK GQNCLEVRTR RRRKDDAPPH YPPPSTAAAS 480
PAGLDLSNGH LDTFRLSLAR FWEQSAPTGP PVSTPGPPDD DEEEGAPTTP QAEGAMESS 540
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--POZ_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0030154--P:cell differentiation
GO:0007398--P:ectoderm development
GO:0007275--P:multicellular organismal development
GO:0010628--P:positive regulation of gene expression
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter