dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000873
Uniprot Accession O15151; MDM4_HUMAN; Q2M2Y2; Q32SL2; Q6GS18; Q8IV83;
Genbank Protein ID NP_001191100.1; NP_001191101.1; NP_001265445.1; NP_001265446.1; NP_001265447.1; NP_001265448.1; NP_002384.2;
Genbank Nucleotide ID NM_001204171.1; NM_001204172.1; NM_001278516.1; NM_001278517.1; NM_001278518.1; NM_001278519.1; NM_002393.4;
Protein Name Protein Mdm4
Protein Synonyms/Alias Double minute 4 protein;Mdm2-like p53-binding protein;Protein Mdmx;p53-binding protein Mdm4;
Gene Name MDM4
Gene Synonyms/Alias MDMX;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
20SDSACRISPGQINQVPhosphoSitePlus;curated22135298; 25627689
55TVKEVMHYLGQYIMVdbPTM 3.0;PhosphoSitePlus;curated19075013; 16381945; 23193290; 22135298; 22817900
96SFSVKDPSPLYDMLRdbPTM 3.0;PhosphoSitePlus;curated15735705; 16381945; 23193290; 22135298; 22817900
99VKDPSPLYDMLRKNLdbPTM 3.0;PhosphoSitePlus;curated19075013; 16381945; 23193290; 22135298; 22817900
119ATTDAAQTLALAQDHPhosphoSitePlus22135298
161DIPTLPTSEHKCIHSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16163388; 16381945; 23193290; 18988627; 22135298; 23186163
263EAADTEQTSEEVGKVPhosphoSitePlus22135298
264AADTEQTSEEVGKVSPhosphoSitePlus22135298
289DDLEDSKSLSDDTDVdbPTM 3.0;PhosphoSitePlus;curated16024788; 16381945; 23193290; 22135298; 22817900
314TECKKFNSPSKRYCFcurated25849741
340DCSKLTHSLSTSDITcurated25627689
342SKLTHSLSTSDITAIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16163388; 16381945; 23193290; 15788536; 16943424; 19075013;
343KLTHSLSTSDITAIPcurated25627689
344LTHSLSTSDITAIPEcurated25627689
365DVPDCRRTISAPVVRdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated15788536; 16381945; 23193290; 18988627; 22135298; 22817900
367PDCRRTISAPVVRPKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated16163388; 16511572; 16381945; 23193290; 15788536; 16227609;
391KLFDPCNSVEFLDLAdbPTM 3.0;HPRD 916163388; 16511560; 16381945; 23193290; 18988627
403DLAHSSESQETISSMdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated15788536; 16163388; 19432880; 19808970; 16381945; 23193290;
Sequence
(Fasta)		MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL 120
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ 180
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF 240
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS 300
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP 360
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ 420
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE 480
IQLVIKVFIA 491
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2
Pfam

PF02201--SWIB
PF00641--zf-RanBP
Gene Ontology

GO:0005634--C:nucleus
GO:0019899--F:enzyme binding
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0008285--P:negative regulation of cell proliferation
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization