dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000871
Uniprot Accession O15145; ARPC3_HUMAN; O00554;
Genbank Protein ID NP_001265485.1; NP_001274151.1;
Genbank Nucleotide ID NM_001278556.1; NM_001287222.1;
Protein Name Actin-related protein 2/3 complex subunit 3
Protein Synonyms/Alias Arp2/3 complex 21 kDa subunit;p21-ARC;
Gene Name ARPC3
Gene Synonyms/Alias ARC21;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Phosphorylation Sites
 dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
4----MPAYHSSLMDPPhosphoSitePlus22135298
13SSLMDPDTKLIGNMAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus19413330; 16381945; 23193290; 18988627; 21081558; 22135298
47DIVDEAIYYFKANVFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated18083107; 19690332; 16381945; 23193290; 18180459; 20090780;
48IVDEAIYYFKANVFFPhosphoSitePlus22135298
Sequence
(Fasta)		MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI 60
KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP 120
ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ 179
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR007204--ARPC3
PROSITE
Pfam

PF04062--P21-Arc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087--P:innate immune response
GO:0006928--P:movement of cell or subcellular component
GO:0007264--P:small GTPase mediated signal transduction