dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000870
Uniprot Accession O15144; ARPC2_HUMAN; Q92801; Q9P1D4;
Genbank Protein ID NP_005722.1; NP_690601.1;
Genbank Nucleotide ID NM_005731.3; NM_152862.2;
Protein Name Actin-related protein 2/3 complex subunit 2
Protein Synonyms/Alias Arp2/3 complex 34 kDa subunit;p34-ARC;
Gene Name ARPC2
Gene Synonyms/Alias ARC34;PRO2446;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
108NLPASKDSIVHQAGMdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
123LKRNCFASVFEKYFQPhosphoSitePlus22135298
151IHYRDDETMYVESKKPhosphoSitePlus22135298
153YRDDETMYVESKKDRPhosphoSitePlus22135298
156DETMYVESKKDRVTVPhosphoSitePlus22135298
192FKEGRRASHTAPQVLcurated20873877
194EGRRASHTAPQVLFSPhosphoSitePlus;curated22135298; 20873877; 24667141
240NASARDNTINLIHTFdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
250LIHTFRDYLHYHIKCdbPTM 3.0;PhosphoSitePlus20393185; 16381945; 23193290; 22135298
261HIKCSKAYIHTRMRAPhosphoSitePlus22135298
296MKTITGKTFSSR---PhosphoSitePlus22135298
298TITGKTFSSR-----curated26074081
Sequence
(Fasta)		MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS 60
LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC 120
FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV 180
FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT 240
INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR 300
301
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR007188--ARPC2
PROSITE
Pfam

PF04045--P34-Arc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0031252--C:cell leading edge
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087--P:innate immune response
GO:0006928--P:movement of cell or subcellular component
GO:0010592--P:positive regulation of lamellipodium assembly
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0007264--P:small GTPase mediated signal transduction