dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000869
Uniprot Accession O15143; ARC1B_HUMAN; Q9BU00;
Genbank Protein ID NP_005711.1; XP_006715888.1; XP_006715889.1;
Genbank Nucleotide ID NM_005720.3; XM_006715825.1; XM_006715826.1;
Protein Name Actin-related protein 2/3 complex subunit 1B
Protein Synonyms/Alias Arp2/3 complex 41 kDa subunit;p41-ARC;
Gene Name ARPC1B
Gene Synonyms/Alias ARC41;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
21HAWNKDRTQIAICPNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated14749719; 20603326; 16381945; 23193290; 18988627; 22135298;
35NNHEVHIYEKSGAKWPhosphoSitePlus22135298
89KGRTWKPTLVILRINdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
170DFKCRIFSAYIKEVEdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 20736484; 21406692; 16381945; 23193290; 19651622;
172KCRIFSAYIKEVEERdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 21406692; 16381945; 23193290; 19651622; 18988627;
297QSSQRGLTARERFQNdbPTM 3.0;PhosphoSitePlus;curated20068230; 16381945; 23193290; 22135298; 22817900
310QNLDKKASSEGGTAAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17287340; 16381945; 23193290; 17081983; 20068231; 18988627;
311NLDKKASSEGGTAAGdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18707149; 16381945; 23193290; 18988627; 22135298; 19366988;
315KASSEGGTAAGAGLDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 18988627; 21081558; 22135298;
328LDSLHKNSVSQISVLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
330SLHKNSVSQISVLSGdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
336VSQISVLSGGKAKCSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25850435;
355TGMDGGMSIWDVKSLdbPTM 3.0;PhosphoSitePlus;curated20068230; 16381945; 23193290; 22135298; 22817900
361MSIWDVKSLESALKDcurated20873877
364WDVKSLESALKDLKIcurated20873877
Sequence
(Fasta)		MAYHSFLVEP ISCHAWNKDR TQIAICPNNH EVHIYEKSGA KWTKVHELKE HNGQVTGIDW 60
APESNRIVTC GTDRNAYVWT LKGRTWKPTL VILRINRAAR CVRWAPNENK FAVGSGSRVI 120
SICYFEQEND WWVCKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRIFS AYIKEVEERP 180
APTPWGSKMP FGELMFESSS SCGWVHGVCF SASGSRVAWV SHDSTVCLAD ADKKMAVATL 240
ASETLPLLAL TFITDNSLVA AGHDCFPVLF TYDAAAGMLS FGGRLDVPKQ SSQRGLTARE 300
RFQNLDKKAS SEGGTAAGAG LDSLHKNSVS QISVLSGGKA KCSQFCTTGM DGGMSIWDVK 360
SLESALKDLK IK 373
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR030141--ARC1B
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005200--F:structural constituent of cytoskeleton
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0007411--P:axon guidance
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087--P:innate immune response
GO:0006928--P:movement of cell or subcellular component
GO:0007264--P:small GTPase mediated signal transduction