| Tag |
Content |
| dbPAF ID |
dbPAF-0000865 |
| Uniprot Accession |
O15123; ANGP2_HUMAN; A0AV38; A8K205; B7ZLM7; Q9NRR7; Q9P2Y7;
|
| Genbank Protein ID |
NP_001112359.1; NP_001112360.1; NP_001138.1;
|
| Genbank Nucleotide ID |
NM_001118887.1; NM_001118888.1; NM_001147.2;
|
| Protein Name |
Angiopoietin-2 |
| Protein Synonyms/Alias |
|
| Gene Name |
ANGPT2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.Functional Description
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY 60
VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ 120
TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE 180
INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN 240
NSVLQKQQHD LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL 300
TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS GEYWLGNEFV 360
SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR IHLKGLTGTA GKISSISQPG 420
NDFSTKDGDN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS 480
GYSLKATTMM IRPADF
497Fasta Sequence
>O15123|ANGPT2|Homo sapiens(Human)
MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR028844--Ang-2
IPR014716--Fibrinogen_a/b/g_C_1
IPR014715--Fibrinogen_a/b/g_C_2
IPR002181--Fibrinogen_a/b/g_C_dom
IPR020837--Fibrinogen_CS
|
| PROSITE |
PS00514--FIBRINOGEN_C_1
PS51406--FIBRINOGEN_C_2
|
| Pfam |
PF00147--Fibrinogen_C
|
| Gene Ontology |
GO:0042995--C:cell projection
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005102--F:receptor binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0001525--P:angiogenesis
GO:0007596--P:blood coagulation
GO:0071363--P:cellular response to growth factor stimulus
GO:0007281--P:germ cell development
GO:0072012--P:glomerulus vasculature development
GO:0050900--P:leukocyte migration
GO:0060135--P:maternal process involved in female pregnancy
GO:0016525--P:negative regulation of angiogenesis
GO:0043537--P:negative regulation of blood vessel endothelial cell migration
GO:0010812--P:negative regulation of cell-substrate adhesion
GO:0050928--P:negative regulation of positive chemotaxis
GO:0031100--P:organ regeneration
GO:0045766--P:positive regulation of angiogenesis
GO:0014823--P:response to activity
GO:0009749--P:response to glucose
GO:0001666--P:response to hypoxia
GO:0009612--P:response to mechanical stimulus
GO:0014070--P:response to organic cyclic compound
GO:0009314--P:response to radiation
GO:0007165--P:signal transduction
GO:0048014--P:Tie signaling pathway
|
