| Tag |
Content |
| dbPAF ID |
dbPAF-0000864 |
| Uniprot Accession |
O15121; DEGS1_HUMAN;
|
| Genbank Protein ID |
NP_003667.1;
|
| Genbank Nucleotide ID |
NM_003676.3;
|
| Protein Name |
Sphingolipid delta(4)-desaturase DES1 |
| Protein Synonyms/Alias |
Cell migration-inducing gene 15 protein;Degenerative spermatocyte homolog 1;Membrane lipid desaturase; |
| Gene Name |
DEGS1 |
| Gene Synonyms/Alias |
DES1;MLD;MIG15; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).Functional Description
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MGSRVSREDF EWVYTDQPHA DRRREILAKY PEIKSLMKPD PNLIWIIIMM VLTQLGAFYI 60
VKDLDWKWVI FGAYAFGSCI NHSMTLAIHE IAHNAAFGNC KAMWNRWFGM FANLPIGIPY 120
SISFKRYHMD HHRYLGADGV DVDIPTDFEG WFFCTAFRKF IWVILQPLFY AFRPLFINPK 180
PITYLEVINT VAQVTFDILI YYFLGIKSLV YMLAASLLGL GLHPISGHFI AEHYMFLKGH 240
ETYSYYGPLN LLTFNVGYHN EHHDFPNIPG KSLPLVRKIA AEYYDNLPHY NSWIKVLYDF 300
VMDDTISPYS RMKRHQKGEM VLE
324Fasta Sequence
>O15121|DEGS1|Homo sapiens(Human)
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE
|
| Keyword |
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0519--Myristate
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR031196--DES1
IPR011388--DES1/DES2
IPR005804--Fatty_acid_desaturase_dom
IPR013866--Sphingolipid_d4-desaturase_N
|
| PROSITE |
|
| Pfam |
PF00487--FA_desaturase
PF08557--Lipid_DES
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0009055--F:electron carrier activity
GO:0042284--F:sphingolipid delta-4 desaturase activity
GO:0046513--P:ceramide biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0030148--P:sphingolipid biosynthetic process
GO:0006665--P:sphingolipid metabolic process
GO:0006636--P:unsaturated fatty acid biosynthetic process
|
