| Tag |
Content |
| dbPAF ID |
dbPAF-0000863 |
| Uniprot Accession |
O15120; PLCB_HUMAN; O00516; O15106; Q5VUD3; Q5VUD4; Q9BSV7; Q9BWR7;
|
| Genbank Protein ID |
NP_001012745.1; NP_006403.2;
|
| Genbank Nucleotide ID |
NM_001012727.1; NM_006412.3;
|
| Protein Name |
1-acyl-sn-glycerol-3-phosphate acyltransferase beta |
| Protein Synonyms/Alias |
1-acylglycerol-3-phosphate O-acyltransferase 2;1-AGP acyltransferase 2;1-AGPAT 2;Lysophosphatidic acid acyltransferase beta;LPAAT-beta; |
| Gene Name |
AGPAT2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.Functional Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM 60
SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK 120
RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENLKVWIY PEGTRNDNGD 180
LLPFKKGAFY LAVQAQVPIV PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD 240
VPALVDTCHR AMRTTFLHIS KTPQENGATA GSGVQPAQ
279Fasta Sequence
>O15120|AGPAT2|Homo sapiens(Human)
MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ
|
| Keyword |
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1022--Congenital generalized lipodystrophy
KW-0219--Diabetes mellitus
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0594--Phospholipid biosynthesis
KW-1208--Phospholipid metabolism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR004552--AGP_acyltrans
IPR002123--Plipid/glycerol_acylTrfase
|
| PROSITE |
|
| Pfam |
PF01553--Acyltransferase
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0003841--F:1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016024--P:CDP-diacylglycerol biosynthetic process
GO:0044255--P:cellular lipid metabolic process
GO:0008544--P:epidermis development
GO:0046474--P:glycerophospholipid biosynthetic process
GO:0006654--P:phosphatidic acid biosynthetic process
GO:0006644--P:phospholipid metabolic process
GO:0001819--P:positive regulation of cytokine production
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0044281--P:small molecule metabolic process
GO:0019432--P:triglyceride biosynthetic process
|
