dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000862
Uniprot Accession O15119; TBX3_HUMAN; Q8TB20; Q9UKF8;
Genbank Protein ID NP_005987.3; NP_057653.3;
Genbank Nucleotide ID NM_005996.3; NM_016569.3;
Protein Name T-box transcription factor TBX3
Protein Synonyms/Alias
Gene Name TBX3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Phosphorylation Sites
dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
121DQFHKRGTEMVITKSPhosphoSitePlus22135298
163IAADDCRYKFHNSRWPhosphoSitePlus22135298
185PEMPKRMYIHPDSPAPhosphoSitePlus22135298
203QWMSKVVTFHKLKLTPhosphoSitePlus22135298
265NDILKLPYSTFRTYLPhosphoSitePlus22135298
354NCFAQASSPAASTVGcurated25627689
371NLKDLCPSEGESDAEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 18988627; 22135298;
375LCPSEGESDAEAESKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18988627; 22135298; 25627689;
381ESDAEAESKEEHGPEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
396ACDAAKISTTTSEEPPhosphoSitePlus22135298
400AKISTTTSEEPCRDKPhosphoSitePlus22135298
409EPCRDKGSPAVKAHLPhosphoSitePlus;curated22135298; 24961811
432SGRLDKASPDSRHSPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated18220336; 16381945; 23193290; 19276368; 20363803; 22135298;
435LDKASPDSRHSPATIdbPTM 3.0;PhosphoSitePlus;curated19276368; 20363803; 16381945; 23193290; 22135298; 25627689;
438ASPDSRHSPATISSSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated18220336; 16381945; 23193290; 19276368; 22135298; 24275569;
441DSRHSPATISSSTRGdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated18220336; 16381945; 23193290; 19276368; 22135298; 25627689;
443RHSPATISSSTRGLGdbPTM 3.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 22135298; 22817900
444HSPATISSSTRGLGAPhosphoSitePlus22135298
445SPATISSSTRGLGAEdbPTM 3.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 22135298; 22817900
446PATISSSTRGLGAEEdbPTM 3.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG AAALSLPGAL 60
AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEEVE DDPKVHLEAK ELWDQFHKRG 120
TEMVITKSGR RMFPPFKVRC SGLDKKAKYI LLMDIIAADD CRYKFHNSRW MVAGKADPEM 180
PKRMYIHPDS PATGEQWMSK VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT 240
ILNSMHKYQP RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA 300
KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KENGTSDESS SEQAAFNCFA QASSPAASTV 360
GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE 420
RPRDSGRLDK ASPDSRHSPA TISSSTRGLG AEERRSPVRE GTAPAKVEEA RALPGKEAFA 480
PLTVQTDAAA AHLAQGPLPG LGFAPGLAGQ QFFNGHPLFL HPSQFAMGGA FSSMAAAGMG 540
PLLATVSGAS TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL 600
FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNTMRPRLRY SPYSIPVPVP DGSSLLTTAL 660
PSMAAAAGPL DGKVAALAAS PASVAVDSGS ELNSRSSTLS SSSMSLSPKL CAEKEAATSE 720
LQSIQRLVSG LEAKPDRSRS ASP 744
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR008967--p53-like_TF_DNA-bd
IPR022582--TBX
IPR001699--TF_T-box
IPR018186--TF_T-box_CS

PROSITE

PS01283--TBOX_1
PS01264--TBOX_2
PS50252--TBOX_3

Pfam

PF00907--T-box
PF12598--TBX

Gene Ontology

GO:0005634--C:nucleus
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0003167--P:atrioventricular bundle cell differentiation
GO:0001568--P:blood vessel development
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0060923--P:cardiac muscle cell fate commitment
GO:0007569--P:cell aging
GO:0090398--P:cellular senescence
GO:0042733--P:embryonic digit morphogenesis
GO:0035115--P:embryonic forelimb morphogenesis
GO:0035116--P:embryonic hindlimb morphogenesis
GO:0030540--P:female genitalia development
GO:0046884--P:follicle-stimulating hormone secretion
GO:0035136--P:forelimb morphogenesis
GO:0001947--P:heart looping
GO:0001701--P:in utero embryonic development
GO:0021761--P:limbic system development
GO:0032275--P:luteinizing hormone secretion
GO:0030539--P:male genitalia development
GO:0030879--P:mammary gland development
GO:0060596--P:mammary placode formation
GO:0048332--P:mesoderm morphogenesis
GO:0043066--P:negative regulation of apoptotic process
GO:0030857--P:negative regulation of epithelial cell differentiation
GO:0045662--P:negative regulation of myoblast differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009887--P:organ morphogenesis
GO:0003151--P:outflow tract morphogenesis
GO:0060021--P:palate development
GO:0045787--P:positive regulation of cell cycle
GO:0008284--P:positive regulation of cell proliferation
GO:2000648--P:positive regulation of stem cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060931--P:sinoatrial node cell development
GO:0001501--P:skeletal system development
GO:0010159--P:specification of organ position
GO:0019827--P:stem cell population maintenance
GO:0006351--P:transcription, DNA-templated
GO:0060412--P:ventricular septum morphogenesis