dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000860
Uniprot Accession O15117; FYB_HUMAN; A8K2Y8; B4DLN2; E9PBV9; O00359; Q9NZI9;
Genbank Protein ID NP_001230022.1; NP_001456.3; NP_955367.1; XP_006714527.1; XP_006714528.1; XP_006714529.1; XP_011512310.1; XP_011512311.1; XP_011512312.1;
Genbank Nucleotide ID NM_001243093.1; NM_001465.4; NM_199335.3; XM_006714464.2; XM_006714465.2; XM_006714466.2; XM_011514008.1; XM_011514009.1; XM_011514010.1;
Protein Name FYN-binding protein
Protein Synonyms/Alias Adhesion and degranulation promoting adaptor protein;ADAP;FYB-120/130;p120/p130;FYN-T-binding protein;SLAP-130;SLP-76-associated phosphoprotein;
Gene Name FYB
Gene Synonyms/Alias SLAP130;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Phosphorylation Sites
 dbPAF PTMs: 46 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MAKYNTGGNPTdbPTM 3.0;PhosphoSitePlus15570572; 16381945; 23193290; 22135298
28FRVTGPNSSSGIQARPhosphoPep 2.019060867
46FNNQGNASPPAGPSNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18088087; 19690332; 16381945; 23193290; 20058876; 18988627;
158LGPKSGPTPPTSENEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.018088087; 16381945; 23193290; 18988627; 19060867; 22135298;
161KSGPTPPTSENEQKQdbPTM 3.0;HPRD 9;PhosphoSitePlus18491316; 16381945; 23193290; 18988627; 22135298
184KGKFMSASQDLEPKPcurated23917254
205FGQKPPLSTENSHEDcurated23090842
206GQKPPLSTENSHEDEcurated23090842; 26074081
209PPLSTENSHEDESPMdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 23917254; 26074081
214ENSHEDESPMKNVSScurated23090842; 26074081
222PMKNVSSSKGSPAPLPhosphoSitePlus22135298
225NVSSSKGSPAPLGVRPhosphoSitePlus;curated22135298; 23917254; 23186163; 26074081
233PAPLGVRSKSGPLKPPhosphoSitePlus22135298
235PLGVRSKSGPLKPARcurated26074081
245LKPAREDSENKDHAGPhosphoSitePlus22135298
306INQEELASGTPPARFPhosphoSitePlus;curated22135298; 26074081
308QEELASGTPPARFPKPhosphoSitePlus;curated22135298; 26074081
318ARFPKAPSKLTVGGPcurated26074081
329VGGPWGQSQEKEKGDPhosphoSitePlus;curated22135298; 23917254
374DLTKFHKTSSGNSTSPhosphoSitePlus22135298
Sequence
(Fasta)		MAKYNTGGNP TEDVSVNSRP FRVTGPNSSS GIQARKNLFN NQGNASPPAG PSNVPKFGSP 60
KPPVAVKPSS EEKPDKEPKP PFLKPTGAGQ RFGTPASLTT RDPEAKVGFL KPVGPKPINL 120
PKEDSKPTFP WPPGNKPSLH SVNQDHDLKP LGPKSGPTPP TSENEQKQAF PKLTGVKGKF 180
MSASQDLEPK PLFPKPAFGQ KPPLSTENSH EDESPMKNVS SSKGSPAPLG VRSKSGPLKP 240
AREDSENKDH AGEISSLPFP GVVLKPAASR GGPGLSKNGE EKKEDRKIDA AKNTFQSKIN 300
QEELASGTPP ARFPKAPSKL TVGGPWGQSQ EKEKGDKNSA TPKQKPLPPL FTLGPPPPKP 360
NRPPNVDLTK FHKTSSGNST SKGQTSYSTT SLPPPPPSHP ASQPPLPASH PSQPPVPSLP 420
PRNIKPPFDL KSPVNEDNQD GVTHSDGAGN LDEEQDSEGE TYEDIEASKE REKKREKEEK 480
KRLELEKKEQ KEKEKKEQEI KKKFKLTGPI QVIHLAKACC DVKGGKNELS FKQGEQIEII 540
RITDNPEGKW LGRTARGSYG YIKTTAVEID YDSLKLKKDS LGAPSRPIED DQEVYDDVAE 600
QDDISSHSQS GSGGIFPPPP DDDIYDGIEE EDADDGFPAP PKQLDMGDEV YDDVDTSDFP 660
VSSAEMSQGT NVGKAKTEEK DLKKLKKQEK EEKDFRKKFK YDGEIRVLYS TKVTTSITSK 720
KWGTRDLQVK PGESLEVIQT TDDTKVLCRN EEGKYGYVLR SYLADNDGEI YDDIADGCIY 780
DND 784
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR030635--FYB
IPR029294--hSH3
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE
Pfam

PF14603--hSH3
PF07653--SH3_2
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005102--F:receptor binding
GO:0006955--P:immune response
GO:0035556--P:intracellular signal transduction
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0072659--P:protein localization to plasma membrane
GO:0006468--P:protein phosphorylation
GO:0007165--P:signal transduction
GO:0050852--P:T cell receptor signaling pathway