| Tag |
Content |
| dbPAF ID |
dbPAF-0000857 |
| Uniprot Accession |
O15105; SMAD7_HUMAN; B7Z773; K7EQ10; O14740; Q6DK23;
|
| Genbank Protein ID |
NP_001177750.1; NP_001177751.1; NP_001177752.1; NP_005895.1;
|
| Genbank Nucleotide ID |
NM_001190821.1; NM_001190822.1; NM_001190823.1; NM_005904.3;
|
| Protein Name |
Mothers against decapentaplegic homolog 7 |
| Protein Synonyms/Alias |
|
| Gene Name |
SMAD7 |
| Gene Synonyms/Alias |
MADH7;MADH8; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).Functional Description
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MFRTKRSALV RRLWRSRAPG GEDEEEGAGG GGGGGELRGE GATDSRAHGA GGGGPGRAGC 60
CLGKAVRGAK GHHHPHPPAA GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG 120
TRTACLLLPG RLDCRLGPGA PAGAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC 180
ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTADCPDAVP SSAETGGTNY 240
LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ 300
LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV 360
FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE 420
VIFNSR
427Fasta Sequence
>O15105|SMAD7|Homo sapiens(Human)
MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
|
| Interpro |
IPR013790--Dwarfin
IPR003619--MAD_homology1_Dwarfin-type
IPR013019--MAD_homology_MH1
IPR017855--SMAD_dom-like
IPR001132--SMAD_dom_Dwarfin-type
IPR008984--SMAD_FHA_domain
|
| PROSITE |
PS51075--MH1
PS51076--MH2
|
| Pfam |
PF03165--MH1
PF03166--MH2
|
| Gene Ontology |
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0005667--C:transcription factor complex
GO:0048185--F:activin binding
GO:0008013--F:beta-catenin binding
GO:0070411--F:I-SMAD binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0030617--F:transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0034713--F:type I transforming growth factor beta receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0034333--P:adherens junction assembly
GO:0048844--P:artery morphogenesis
GO:0030509--P:BMP signaling pathway
GO:0034629--P:cellular protein complex localization
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0010467--P:gene expression
GO:0035556--P:intracellular signal transduction
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0010719--P:negative regulation of epithelial to mesenchymal transition
GO:0060394--P:negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:0010801--P:negative regulation of peptidyl-threonine phosphorylation
GO:0031397--P:negative regulation of protein ubiquitination
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010944--P:negative regulation of transcription by competitive promoter binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0022409--P:positive regulation of cell-cell adhesion
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0050821--P:protein stabilization
GO:0032925--P:regulation of activin receptor signaling pathway
GO:0055117--P:regulation of cardiac muscle contraction
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway
GO:0060373--P:regulation of ventricular cardiac muscle cell membrane depolarization
GO:0034616--P:response to laminar fluid shear stress
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0001657--P:ureteric bud development
GO:0055010--P:ventricular cardiac muscle tissue morphogenesis
GO:0060412--P:ventricular septum morphogenesis
|
