dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000855
Uniprot Accession O15090; ZN536_HUMAN; A2RU18;
Genbank Protein ID NP_055532.1;
Genbank Nucleotide ID NM_014717.2;
Protein Name Zinc finger protein 536
Protein Synonyms/Alias
Gene Name ZNF536
Gene Synonyms/Alias KIAA0390;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
5---MEEASLCLGVSSPhosphoSitePlus22135298
151ILSLHMRTHTGEKPFPhosphoSitePlus22135298
153SLHMRTHTGEKPFKCPhosphoSitePlus;curated22135298; 22817900
405KLSVKNKSPSDPEVPcurated23403867
407SVKNKSPSDPEVPVPcurated23403867
676DERRGSGSDQESQSVcurated20363803
680GSGSDQESQSVSRSTPhosphoSitePlus22135298
682GSDQESQSVSRSTTPPhosphoSitePlus22135298
774KVHLRIHTGEKPYKCPhosphoSitePlus22135298
826QDHKDEMSSKASLFIdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 22817900
827DHKDEMSSKASLFIRdbPTM 3.0;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 22135298; 22817900
874GDHSGQATGMSSEVPPhosphoSitePlus22135298
973RKSEKSQYEPLDLSVPhosphoSitePlus22135298
1141EPDGKAHSEEDVPILcurated25850435
Sequence
(Fasta)		MEEASLCLGV SSAEPEAEPH LSGPVLNGQY AMSQKLHQIT SQLSHAFPEL HPRPNPEEKP 60
PASLEEKAHV PMSGQPMGSQ MALLANQLGR EVDTSLNGRV DLQQFLNGQN LGIMSQMSDI 120
EDDARKNRKY PCPLCGKRFR FNSILSLHMR THTGEKPFKC PYCDHRAAQK GNLKIHLRTH 180
KLGNLGKGRG RVREENRLLH ELEERAILRD KQLKGSLLQP RPDLKPPPHA QQAPLAACTL 240
ALQANHSVPD VAHPVPSPKP ASVQEDAVAP AAGFRCTFCK GKFKKREELD RHIRILHKPY 300
KCTLCDFAAS QEEELISHVE KAHITAESAQ GQGPNGGGEQ SANEFRCEVC GQVFSQAWFL 360
KGHMRKHKDS FEHCCQICGR RFKEPWFLKN HMKVHLNKLS VKNKSPSDPE VPVPMGGMSQ 420
EAHANLYSRY LSCLQSGFMT PDKAGLSEPS QLYGKGELPM KEKEALGKLL SPISSMAHGV 480
PEGDKHSLLG CLNLVPPLKS SCIERLQAAA KAAEMDPVNS YQAWQLMARG MAMEHGFLSK 540
EHPLQRNHED TLANAGVLFD KEKREYVLVG ADGSKQKMPA DLVHSTKVGS QRDLPSKLDP 600
LESSRDFLSH GLNQTLEYNL QGPGNMKEKP TECPDCGRVF RTYHQVVVHS RVHKRDRKGE 660
EDGLHVGLDE RRGSGSDQES QSVSRSTTPG SSNVTEESGV GGGLSQTGSA QEDSPHPSSP 720
SSSDIGEEAG RSAGVQQPAL LRDRSLGSAM KDCPYCGKTF RTSHHLKVHL RIHTGEKPYK 780
CPHCDYAGTQ SASLKYHLER HHRERQNGAG PLSGQPPNQD HKDEMSSKAS LFIRPDILRG 840
AFKGLPGIDF RGGPASQQWT SGVLSSGDHS GQATGMSSEV PSDALKGTDL PSKSTHFSEI 900
GRAYQSIVSN GVNFQGSLQA FMDSFVLSSL KKEKDMKDKA LADPPSMKVH GVDGGEEKPS 960
GKSSQRKSEK SQYEPLDLSV RPDAASLPGS SVTVQDSIAW HGCLFCAFTT SSMELMALHL 1020
QANHLGKAKR KDNTIGVTVN CKDQAREASK MALLPSLQSN KDLGLSNMIS SLDSASEKMA 1080
QGQLKETLGE QKSGAWTGHV DPAFCNFPSD FYKQFGVYPG MVGSGASSSC PNKEPDGKAH 1140
SEEDVPILIP ETTSKNTTDD LSDIASSEDM DSSKGENNDE EDVETEPEMM TKPLSALSKD 1200
SSSDGGDSLQ PTGTSQPVQG LVSPLSQAPE KQWHSQGLLQ AQDPLAGLPK PERGPQSLDK 1260
PMNMLSVLRA YSSDGLAAFN GLASSTANSG CIKRPDLCGK 1301
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00096--zf-C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0044323--F:retinoic acid-responsive element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0007275--P:multicellular organismal development
GO:0045665--P:negative regulation of neuron differentiation
GO:0048387--P:negative regulation of retinoic acid receptor signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated