dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000854
Uniprot Accession O15085; ARHGB_HUMAN; D3DVD0; Q5VY40; Q6PFW2;
Genbank Protein ID NP_055599.1; NP_937879.1;
Genbank Nucleotide ID NM_014784.3; NM_198236.2;
Protein Name Rho guanine nucleotide exchange factor 11
Protein Synonyms/Alias PDZ-RhoGEF;
Gene Name ARHGEF11
Gene Synonyms/Alias KIAA0380;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Phosphorylation Sites
 dbPAF PTMs: 70 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSVRLPQSIPhosphoSitePlus;curated22135298; 23186163
14QSIDRLSSLSSLGDSPhosphoSitePlus;curated22135298; 25850435; 25627689
16IDRLSSLSSLGDSAPPhosphoSitePlus;curated22135298; 25850435
17DRLSSLSSLGDSAPEcurated25850435
27DSAPERKSPSHHRQPPhosphoSitePlus22135298
29APERKSPSHHRQPSDPhosphoSitePlus22135298
35PSHHRQPSDASETTGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25850435;
38HRQPSDASETTGLVQPhosphoSitePlus22135298
40QPSDASETTGLVQRCPhosphoSitePlus22135298
41PSDASETTGLVQRCVPhosphoSitePlus22135298
150RITSVIPSPPPPPPLPhosphoSitePlus;curated22135298; 25850435; 25627689; 24117733
208GDTSQRPSEGRLSLDPhosphoSitePlus22135298
213RPSEGRLSLDSQEGDcurated25850435; 23663014
216EGRLSLDSQEGDSGLPhosphoSitePlus;curated22135298; 25850435; 23663014
225EGDSGLDSGTERFPScurated25850435
232SGTERFPSLSESLMNcurated25850435
242ESLMNRNSVLSDPGLcurated25850435; 23090842
245MNRNSVLSDPGLDSPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 20068231; 20363803; 18988627;
251LSDPGLDSPRTSPVIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 17081983; 19362540;
254PGLDSPRTSPVIMARdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 20363803; 21659604;
Sequence
(Fasta)		MSVRLPQSID RLSSLSSLGD SAPERKSPSH HRQPSDASET TGLVQRCVII QKDQHGFGFT 60
VSGDRIVLVQ SVRPGGAAMK AGVKEGDRII KVNGTMVTNS SHLEVVKLIK SGAYVALTLL 120
GSSPSSMGIS GLQQDPSPAG APRITSVIPS PPPPPPLPPP QRITGPKPLQ DPEVQKHATQ 180
ILRNMLRQEE KELQDILPLY GDTSQRPSEG RLSLDSQEGD SGLDSGTERF PSLSESLMNR 240
NSVLSDPGLD SPRTSPVIMA RVAQHHRRQG SDAAVPSTGD QGVDQSPKPL IIGPEEDYDP 300
GYFNNESDII FQDLEKLKSR PAHLGVFLRY IFSQADPSPL LFYLCAEVYQ QASPKDSRSL 360
GKDIWNIFLE KNAPLRVKIP EMLQAEIDSR LRNSEDARGV LCEAQEAAMP EIQEQIHDYR 420
TKRTLGLGSL YGENDLLDLD GDPLRERQVA EKQLAALGDI LSKYEEDRSA PMDFALNTYM 480
SHAGIRLREA RPSNTAEKAQ SAPDKDKWLP FFPKTKKSSN SKKEKDALED KKRNPILKYI 540
GKPKSSSQST FHIPLSPVEV KPGNVRNIIQ HFENNQQYDA PEPGTQRLST GSFPEDLLES 600
DSSRSEIRLG RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS 660
TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE PDAQNWQHTV 720
GKDVVAGLTQ REIDRQEVIN ELFVTEASHL RTLRVLDLIF YQRMKKENLM PREELARLFP 780
NLPELIEIHN SWCEAMKKLR EEGPIIKEIS DLMLARFDGP AREELQQVAA QFCSYQSIAL 840
ELIKTKQRKE SRFQLFMQEA ESHPQCRRLQ LRDLIISEMQ RLTKYPLLLE SIIKHTEGGT 900
SEHEKLCRAR DQCREILKYV NEAVKQTENR HRLEGYQKRL DATALERASN PLAAEFKSLD 960
LTTRKMIHEG PLTWRISKDK TLDLHVLLLE DLLVLLQKQD EKLLLKCHSK TAVGSSDSKQ 1020
TFSPVLKLNA VLIRSVATDK RAFFIICTSK LGPPQIYELV ALTSSDKNTW MELLEEAVRN 1080
ATRHPGAAPM PVHPPPPGPR EPAQQGPTPS RVELDDSDVF HGEPEPEELP GGTGSQQRVQ 1140
GKHQVLLEDP EQEGSAEEEE LGVLPCPSTS LDGENRGIRT RNPIHLAFPG PLFMEGLADS 1200
ALEDVENLRH LILWSLLPGH TMETQAAQEP EDDLTPTPSV ISVTSHPWDP GSPGQAPPGG 1260
EGDNTQLAGL EGERPEQEDM GLCSLEHLPP RTRNSGIWES PELDRNLAED ASSTEAAGGY 1320
KVVRKAEVAG SKVVPALPES GQSEPGPPEV EGGTKATGNC FYVSMPSGPP DSSTDHSEAP 1380
MSPPQPDSLP AGQTEPQPQL QGGNDDPRRP SRSPPSLALR DVGMIFHTIE QLTLKLNRLK 1440
DMELAHRELL KSLGGESSGG TTPVGSFHTE AARWTDGSLS PPAKEPLASD SRNSHELGPC 1500
PEDGSDAPLE DSTADAAASP GP 1523
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0343--GTPase activation
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR000219--DH-domain
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR016137--RGS
IPR015212--RGS-like_dom
PROSITE

PS50010--DH_2
PS50106--PDZ
PS50003--PH_DOMAIN
PS50132--RGS
Pfam

PF00595--PDZ
PF16652--PH_13
PF09128--RGS-like
PF00621--RhoGEF
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0001664--F:G-protein coupled receptor binding
GO:0005096--F:GTPase activator activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0030036--P:actin cytoskeleton organization
GO:0097190--P:apoptotic signaling pathway
GO:0007411--P:axon guidance
GO:0000910--P:cytokinesis
GO:0030010--P:establishment of cell polarity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006928--P:movement of cell or subcellular component
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:0043547--P:positive regulation of GTPase activity
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0001558--P:regulation of cell growth
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007266--P:Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0006941--P:striated muscle contraction