dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000853
Uniprot Accession O15084; ANR28_HUMAN; B4DES5; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57;
Genbank Protein ID NP_001182027.1; NP_001182028.1; NP_056014.2; XP_005265053.1; XP_011531842.1; XP_011531853.1;
Genbank Nucleotide ID NM_001195098.1; NM_001195099.1; NM_015199.3; XM_005264996.2; XM_011533540.1; XM_011533551.1;
Protein Name Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Protein Synonyms/Alias
Gene Name ANKRD28
Gene Synonyms/Alias KIAA0379;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
142VSDRAGRTALHHAAFPhosphoSitePlus22135298
696ALHRGAVTGHEECVDPhosphoSitePlus22135298
982CLALILATMMPVSSScurated25627689
987LATMMPVSSSSPLSScurated25627689; 26074081
988ATMMPVSSSSPLSSLcurated25627689; 26074081
989TMMPVSSSSPLSSLTdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689
990MMPVSSSSPLSSLTFPhosphoSitePlus;curated22135298; 25627689; 26074081
1003TFNAINRYTNTSKTVPhosphoSitePlus22135298
1007INRYTNTSKTVSFEAdbPTM 3.0;PhosphoSitePlus;UniProt;curated16564677; 16381945; 23193290; 17023142; 22135298; 22817900
1009RYTNTSKTVSFEALPcurated22199227; 24961811
1011TNTSKTVSFEALPIMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated16564677; 19369195; 16381945; 23193290; 18669648; 17023142;
1048DVDELNDSDSETY--dbPTM 3.0;HPRD 9;curated18691976; 16381945; 23193290; 18988627; 26074081
Sequence
(Fasta)		MAFLKLRDQP SLVQAIFNGD PDEVRALIFK KEDVNFQDNE KRTPLHAAAY LGDAEIIELL 60
ILSGARVNAK DSKWLTPLHR AVASCSEEAV QVLLKHSADV NARDKNWQTP LHIAAANKAV 120
KCAEALVPLL SNVNVSDRAG RTALHHAAFS GHGEMVKLLL SRGANINAFD KKDRRAIHWA 180
AYMGHIEVVK LLVSHGAEVT CKDKKSYTPL HAAASSGMIS VVKYLLDLGV DMNEPNAYGN 240
TPLHVACYNG QDVVVNELID CGAIVNQKNE KGFTPLHFAA ASTHGALCLE LLVGNGADVN 300
MKSKDGKTPL HMTALHGRFS RSQTIIQSGA VIDCEDKNGN TPLHIAARYG HELLINTLIT 360
SGADTAKRGI HGMFPLHLAA LSGFSDCCRK LLSSGFDIDT PDDFGRTCLH AAAAGGNLEC 420
LNLLLNTGAD FNKKDKFGRS PLHYAAANCN YQCLFALVGS GASVNDLDER GCTPLHYAAT 480
SDTDGKCLEY LLRNDANPGI RDKQGYNAVH YSAAYGHRLC LQLIASETPL DVLMETSGTD 540
MLSDSDNRAT ISPLHLAAYH GHHQALEVLV QSLLDLDVRN SSGRTPLDLA AFKGHVECVD 600
VLINQGASIL VKDYILKRTP IHAAATNGHS ECLRLLIGNA EPQNAVDIQD GNGQTPLMLS 660
VLNGHTDCVY SLLNKGANVD AKDKWGRTAL HRGAVTGHEE CVDALLQHGA KCLLRDSRGR 720
TPIHLSAACG HIGVLGALLQ SAASMDANPA TADNHGYTAL HWACYNGHET CVELLLEQEV 780
FQKTEGNAFS PLHCAVINDN EGAAEMLIDT LGASIVNATD SKGRTPLHAA AFTDHVECLQ 840
LLLSHNAQVN SVDSTGKTPL MMAAENGQTN TVEMLVSSAS AELTLQDNSK NTALHLACSK 900
GHETSALLIL EKITDRNLIN ATNAALQTPL HVAARNGLTM VVQELLGKGA SVLAVDENGY 960
TPALACAPNK DVADCLALIL ATMMPVSSSS PLSSLTFNAI NRYTNTSKTV SFEALPIMRN 1020
EPSSYCSFNN IGGEQEYLYT DVDELNDSDS ETY 1054
Keyword

KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF00023--Ank
PF12796--Ank_2
Gene Ontology

GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005654--C:nucleoplasm
GO:0044267--P:cellular protein metabolic process
GO:0048208--P:COPII vesicle coating
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0061024--P:membrane organization
GO:0043687--P:post-translational protein modification
GO:0018279--P:protein N-linked glycosylation via asparagine