dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000852
Uniprot Accession O15083; ERC2_HUMAN; Q2T9F6; Q86TK4;
Genbank Protein ID NP_056391.1;
Genbank Nucleotide ID NM_015576.2;
Protein Name ERC protein 2
Protein Synonyms/Alias
Gene Name ERC2
Gene Synonyms/Alias KIAA0378;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
14TITNLEGSPSRSPRLPhosphoPep 2.019060867
18LEGSPSRSPRLPRSPdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
24RSPRLPRSPRLGHRRHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298; 22817900
32PRLGHRRTSSGGGGGdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
34LGHRRTSSGGGGGTGdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
65TSGPMYLSDHEGVASPhosphoSitePlus22135298
178KDSKLGSSMNSIKTFPhosphoSitePlus22135298
184SSMNSIKTFWSPELKcurated24961811
187NSIKTFWSPELKKERdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated17924679; 16381945; 23193290; 18669648; 19276368; 19664994;
314KLLEMLQSKGLPSKSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
319LQSKGLPSKSLEDDNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
321SKGLPSKSLEDDNERPhosphoSitePlus22135298
591ATLEEALSEKERIIEPhosphoSitePlus22135298
713KQLDKEASYYRDECGPhosphoSitePlus22135298
Sequence
(Fasta)		MYGSARTITN LEGSPSRSPR LPRSPRLGHR RTSSGGGGGT GKTLSMENIQ SLNAAYATSG 60
PMYLSDHEGV ASTTYPKGTM TLGRATNRAV YGGRVTAMGS SPNIASAGLS HTDVLSYTDQ 120
HGGLTGSSHH HHHQVPSMLR QVRDSTMLDL QAQLKELQRE NDLLRKELDI KDSKLGSSMN 180
SIKTFWSPEL KKERVLRKEE AARMSVLKEQ MRVSHEENQH LQLTIQALQD ELRTQRDLNH 240
LLQQESGNRG AEHFTIELTE ENFRRLQAEH DRQAKELFLL RKTLEEMELR IETQKQTLNA 300
RDESIKKLLE MLQSKGLPSK SLEDDNERTR RMAEAESQVS HLEVILDQKE KENIHLREEL 360
HRRSQLQPEP AKTKALQTVI EMKDTKIASL ERNIRDLEDE IQMLKANGVL NTEDREEEIK 420
QIEVYKSHSK FMKTKIDQLK QELSKKESEL LALQTKLETL SNQNSDCKQH IEVLKESLTA 480
KEQRAAILQT EVDALRLRLE EKESFLNKKT KQLQDLTEEK GTLAGEIRDM KDMLEVKERK 540
INVLQKKIEN LQEQLRDKDK QLTNLKDRVK SLQTDSSNTD TALATLEEAL SEKERIIERL 600
KEQRERDDRE RLEEIESFRK ENKDLKEKVN ALQAELTEKE SSLIDLKEHA SSLASAGLKR 660
DSKLKSLEIA IEQKKEECSK LEAQLKKAHN IEDDSRMNPE FADQIKQLDK EASYYRDECG 720
KAQAEVDRLL EILKEVENEK NDKDKKIAEL ESLTLRHMKD QNKKVANLKH NQQLEKKKNA 780
QLLEEVRRRE DSMADNSQHL QIEELMNALE KTRQELDATK ARLASTQQSL AEKEAHLANL 840
RIERRKQLEE ILEMKQEALL AAISEKDANI ALLELSASKK KKTQEEVMAL KREKDRLVHQ 900
LKQQTQNRMK LMADNYDDDH HHYHHHHHHH HHRSPGRSQH SNHRPSPDQD DEEGIWA 958
Keyword

KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR019323--ELKS/CAST
PROSITE
Pfam

PF10174--Cast
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0030426--C:growth cone
GO:0048786--C:presynaptic active zone
GO:0042734--C:presynaptic membrane