dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000849
Uniprot Accession O15075; DCLK1_HUMAN; B7Z3E9; Q5VZY8; Q5VZZ0; Q5VZZ1;
Genbank Protein ID NP_001182344.1; NP_001182345.1; NP_004725.1; XP_005266649.1; XP_006719956.1;
Genbank Nucleotide ID NM_001195415.1; NM_001195416.1; NM_004734.4; XM_005266592.2; XM_006719893.2;
Protein Name Serine/threonine-protein kinase DCLK1
Protein Synonyms/Alias Doublecortin domain-containing protein 3A;Doublecortin-like and CAM kinase-like 1;Doublecortin-like kinase 1;
Gene Name DCLK1
Gene Synonyms/Alias DCAMKL1;DCDC3A;KIAA0369;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Phosphorylation Sites
 dbPAF PTMs: 46 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSFGRDMELcurated25849741
32SRVNGLPSPTHSAHCdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 23898821; 25849741
34VNGLPSPTHSAHCSFPhosphoSitePlus;curated22135298; 23898821; 25849741
36GLPSPTHSAHCSFYRcurated23898821; 25849741
46CSFYRTRTLQTLSSEPhosphoSitePlus;curated22135298; 25849741
68FYRNGDRYFKGIVYAPhosphoSitePlus22135298
118IDGLKKISSLDQLVEcurated23898821
119DGLKKISSLDQLVEGcurated23898821
128DQLVEGESYVCGSIEcurated23898821
164TSASRAVSSLATAKGPhosphoSitePlus;curated22135298; 25849741
172SLATAKGSPSEVRENPhosphoSitePlus;curated22135298; 25849741
209RILLNKKTAHSFEQVPhosphoSitePlus22135298
212LNKKTAHSFEQVLTDPhosphoSitePlus22135298
265CGPEKFRYQDDFLLDPhosphoSitePlus22135298
274DDFLLDESECRVVKSPhosphoSitePlus22135298
294IASSSRRSTTKSPGPcurated25849741
296SSSRRSTTKSPGPSRcurated25849741
298SRRSTTKSPGPSRRScurated25849741
305SPGPSRRSKSPASTSdbPTM 3.0;PhosphoSitePlus;curated20363803; 20886841; 16381945; 23193290; 22135298; 23898821;
307GPSRRSKSPASTSSVdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated20886841; 16381945; 23193290; 19060867; 22135298; 23911959;
Sequence
(Fasta)		MSFGRDMELE HFDERDKAQR YSRGSRVNGL PSPTHSAHCS FYRTRTLQTL SSEKKAKKVR 60
FYRNGDRYFK GIVYAISPDR FRSFEALLAD LTRTLSDNVN LPQGVRTIYT IDGLKKISSL 120
DQLVEGESYV CGSIEPFKKL EYTKNVNPNW SVNVKTTSAS RAVSSLATAK GSPSEVRENK 180
DFIRPKLVTI IRSGVKPRKA VRILLNKKTA HSFEQVLTDI TDAIKLDSGV VKRLYTLDGK 240
QVMCLQDFFG DDDIFIACGP EKFRYQDDFL LDESECRVVK STSYTKIASS SRRSTTKSPG 300
PSRRSKSPAS TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG GSSTSLASTK 360
VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN FAVVKECVER STAREYALKI 420
IKKSKCRGKE HMIQNEVSIL RRVKHPNIVL LIEEMDVPTE LYLVMELVKG GDLFDAITST 480
NKYTERDASG MLYNLASAIK YLHSLNIVHR DIKPENLLVY EHQDGSKSLK LGDFGLATIV 540
DGPLYTVCGT PTYVAPEIIA ETGYGLKVDI WAAGVITYIL LCGFPPFRGS GDDQEVLFDQ 600
ILMGQVDFPS PYWDNVSDSA KELITMMLLV DVDQRFSAVQ VLEHPWVNDD GLPENEHQLS 660
VAGKIKKHFN TGPKPNSTAA GVSVIATTAL DKERQVFRRR RNQDVRSRYK AQPAPPELNS 720
ESEDYSPSSS ETVRSPNSPF 741
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0418--Kinase
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR020636--Ca/CaM-dep_Ca-dep_prot_Kinase
IPR003533--Doublecortin_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS50309--DC
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF03607--DCX
PF00069--Pkinase
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0097481--C:neuronal postsynaptic density
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0005057--F:receptor signaling protein activity
GO:0048675--P:axon extension
GO:0007417--P:central nervous system development
GO:0021952--P:central nervous system projection neuron axonogenesis
GO:0048813--P:dendrite morphogenesis
GO:0016197--P:endosomal transport
GO:0030900--P:forebrain development
GO:0007399--P:nervous system development
GO:0001764--P:neuron migration
GO:0006468--P:protein phosphorylation
GO:0009615--P:response to virus