dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000845
Uniprot Accession O15067; PUR4_HUMAN; A6H8V8;
Genbank Protein ID NP_036525.1;
Genbank Nucleotide ID NM_012393.2;
Protein Name Phosphoribosylformylglycinamidine synthase
Protein Synonyms/Alias
Gene Name PFAS
Gene Synonyms/Alias KIAA0361;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
83ESWLLPGSNDLLLEVPhosphoSitePlus22135298
215QELQRNPSTVEAFDLdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 23186163; 22817900
216ELQRNPSTVEAFDLAPhosphoSitePlus22135298
225EAFDLAQSNSEHSRHPhosphoSitePlus22135298
230AQSNSEHSRHWFFKGcurated22817900
457VKVGGPVYRIGVGGGPhosphoSitePlus22135298
530GNVLKELSDPAGAIIdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated21406692; 16381945; 23193290; 21081558; 22135298; 22817900
538DPAGAIIYTSRFQLGPhosphoSitePlus;curated22135298; 22817900
539PAGAIIYTSRFQLGDPhosphoSitePlus22135298
562WGAEYQESNALLLRScurated23898821
569SNALLLRSPNRDFLTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20363803; 21406692;
576SPNRDFLTHVSARERPhosphoSitePlus22135298
593ACFVGTITGDRRIVLPhosphoSitePlus22135298
619GQGDAPPTPLPTPVDdbPTM 3.0;PhosphoSitePlus;UniProt19690332; 16381945; 23193290; 20068231; 22135298
623APPTPLPTPVDLELEdbPTM 3.0;PhosphoSitePlus;UniProt19690332; 16381945; 23193290; 20068231; 22135298
873TALAQCFSQLGEHPPPhosphoSitePlus22135298
893ENLVRAFSITQGLLKPhosphoSitePlus22135298
1053PPTFPKASVPREPGGcurated22817900
1062PREPGGPSPRVAILRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
1119AFVGGFSYADVLGSAPhosphoSitePlus22135298
Sequence
(Fasta)		MSPVLHFYVR PSGHEGAAPG HTRRKLQGKL PELQGVETEL CYNVNWTAEA LPSAEETKKL 60
MWLFGCPLLL DDVARESWLL PGSNDLLLEV GPRLNFSTPT STNIVSVCRA TGLGPVDRVE 120
TTRRYRLSFA HPPSAEVEAI ALATLHDRMT EQHFPHPIQS FSPESMPEPL NGPINILGEG 180
RLALEKANQE LGLALDSWDL DFYTKRFQEL QRNPSTVEAF DLAQSNSEHS RHWFFKGQLH 240
VDGQKLVHSL FESIMSTQES SNPNNVLKFC DNSSAIQGKE VRFLRPEDPT RPSRFQQQQG 300
LRHVVFTAET HNFPTGVCPF SGATTGTGGR IRDVQCTGRG AHVVAGTAGY CFGNLHIPGY 360
NLPWEDPSFQ YPGNFARPLE VAIEASNGAS DYGNKFGEPV LAGFARSLGL QLPDGQRREW 420
IKPIMFSGGI GSMEADHISK EAPEPGMEVV KVGGPVYRIG VGGGAASSVQ VQGDNTSDLD 480
FGAVQRGDPE MEQKMNRVIR ACVEAPKGNP ICSLHDQGAG GNGNVLKELS DPAGAIIYTS 540
RFQLGDPTLN ALEIWGAEYQ ESNALLLRSP NRDFLTHVSA RERCPACFVG TITGDRRIVL 600
VDDRECPVRR NGQGDAPPTP LPTPVDLELE WVLGKMPRKE FFLQRKPPML QPLALPPGLS 660
VHQALERVLR LPAVASKRYL TNKVDRSVGG LVAQQQCVGP LQTPLADVAV VALSHEELIG 720
AATALGEQPV KSLLDPKVAA RLAVAEALTN LVFALVTDLR DVKCSGNWMW AAKLPGEGAA 780
LADACEAMVA VMAALGVAVD GGKDSLSMAA RVGTETVRAP GSLVISAYAV CPDITATVTP 840
DLKHPEGRGH LLYVALSPGQ HRLGGTALAQ CFSQLGEHPP DLDLPENLVR AFSITQGLLK 900
DRLLCSGHDV SDGGLVTCLL EMAFAGNCGL QVDVPVPRVD VLSVLFAEEP GLVLEVQEPD 960
LAQVLKRYRD AGLHCLELGH TGEAGPHAMV RVSVNGAVVL EEPVGELRAL WEETSFQLDR 1020
LQAEPRCVAE EERGLRERMG PSYCLPPTFP KASVPREPGG PSPRVAILRE EGSNGDREMA 1080
DAFHLAGFEV WDVTMQDLCS GAIGLDTFRG VAFVGGFSYA DVLGSAKGWA AAVTFHPRAG 1140
AELRRFRKRP DTFSLGVCNG CQLLALLGWV GGDPNEDAAE MGPDSQPARP GLLLRHNLSG 1200
RYESRWASVR VGPGPALMLR GMEGAVLPVW SAHGEGYVAF SSPELQAQIE ARGLAPLHWA 1260
DDDGNPTEQY PLNPNGSPGG VAGICSCDGR HLAVMPHPER AVRPWQWAWR PPPFDTLTTS 1320
PWLQLFINAR NWTLEGSC 1339
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0315--Glutamine amidotransferase
KW-0436--Ligase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
Interpro

IPR010918--AIR_synth_C_dom
IPR029062--Class_I_gatase-like
IPR017926--GATASE
IPR010073--PRibForGlyAmidine_synth
IPR016188--PurM-like_N
PROSITE

PS51273--GATASE_TYPE_1
Pfam

PF02769--AIRS_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004642--F:phosphoribosylformylglycinamidine synthase activity
GO:0006189--P:'de novo' IMP biosynthetic process
GO:0006541--P:glutamine metabolic process
GO:0055086--P:nucleobase-containing small molecule metabolic process
GO:0006144--P:purine nucleobase metabolic process
GO:0006164--P:purine nucleotide biosynthetic process
GO:0009168--P:purine ribonucleoside monophosphate biosynthetic process
GO:0009156--P:ribonucleoside monophosphate biosynthetic process
GO:0044281--P:small molecule metabolic process