dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000841
Uniprot Accession O15061; SYNEM_HUMAN; A7E2Y2; Q2TBJ4; Q5NJJ9; Q8TE61; Q8TE62;
Genbank Protein ID NP_056101.5; NP_663780.2;
Genbank Nucleotide ID NM_015286.5; NM_145728.2;
Protein Name Synemin
Protein Synonyms/Alias Desmuslin;
Gene Name SYNM
Gene Synonyms/Alias DMN;KIAA0353;SYN;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Phosphorylation Sites
 dbPAF PTMs: 52 (View all)
PositionPeptidesSourceReferences ( PMIDs )
8MLSWRLQTGPEKAELdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
23QELNARLYDYVCRVRPhosphoSitePlus22135298
262LLRMREEYGIQAEERPhosphoSitePlus22135298
294MADWLRDYQDLLQVKdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298
341PSEFRNKSYHYTDSLPhosphoSitePlus;curated22135298; 25627689
375FNHSSALYSNLSGHRPhosphoSitePlus22135298
376NHSSALYSNLSGHRGPhosphoSitePlus22135298
384NLSGHRGSQTGTSIGcurated25850435; 22798277
386SGHRGSQTGTSIGGDcurated22798277
403RGFLGSGYSSSATTQPhosphoSitePlus22135298
405FLGSGYSSSATTQQEPhosphoSitePlus22135298
409GYSSSATTQQENSYGPhosphoSitePlus22135298
415TTQQENSYGKAVSSQPhosphoSitePlus22135298
427SSQTNVRTFSPTYGLPhosphoSitePlus;curated22135298; 24961811
429QTNVRTFSPTYGLLRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 17001009; 19691289; 18988627;
432VRTFSPTYGLLRNTEPhosphoSitePlus22135298
460DTREVPVYIGEDSTIPhosphoSitePlus22135298
489GASESTRSNERTVILcurated25627689
500TVILGKKTEVKATREPhosphoSitePlus22135298
515QERNRPETIRTKPEEPhosphoSitePlus22135298
Sequence
(Fasta)		MLSWRLQTGP EKAELQELNA RLYDYVCRVR ELERENLLLE EELRGRRGRE GLWAEGQARC 60
AEEARSLRQQ LDELSWATAL AEGERDALRR ELRELQRLDA EERAARGRLD AELGAQQREL 120
QEALGARAAL EALLGRLQAE RRGLDAAHER DVRELRARAA SLTMHFRARA TGPAAPPPRL 180
REVHDSYALL VAESWRETVQ LYEDEVRELE EALRRGQESR LQAEEETRLC AQEAEALRRE 240
ALGLEQLRAR LEDALLRMRE EYGIQAEERQ RAIDCLEDEK ATLTLAMADW LRDYQDLLQV 300
KTGLSLEVAT YRALLEGESN PEIVIWAEHV ENMPSEFRNK SYHYTDSLLQ RENERNLFSR 360
QKAPLASFNH SSALYSNLSG HRGSQTGTSI GGDARRGFLG SGYSSSATTQ QENSYGKAVS 420
SQTNVRTFSP TYGLLRNTEA QVKTFPDRPK AGDTREVPVY IGEDSTIARE SYRDRRDKVA 480
AGASESTRSN ERTVILGKKT EVKATREQER NRPETIRTKP EEKMFDSKEK ASEERNLRWE 540
ELTKLDKEAR QRESQQMKEK AKEKDSPKEK SVREREVPIS LEVSQDRRAE VSPKGLQTPV 600
KDAGGGTGRE AEARELRFRL GTSDATGSLQ GDSMTETVAE NIVTSILKQF TQSPETEASA 660
DSFPDTKVTY VDRKELPGER KTKTEIVVES KLTEDVDVSD EAGLDYLLSK DIKEVGLKGK 720
SAEQMIGDII NLGLKGREGR AKVVNVEIVE EPVSYVSGEK PEEFSVPFKV EEVEDVSPGP 780
WGLVKEEEGY GESDVTFSVN QHRRTKQPQE NTTHVEEVTE AGDSEGEQSY FVSTPDEHPG 840
GHDRDDGSVY GQIHIEEEST IRYSWQDEIV QGTRRRTQKD GAVGEKVVKP LDVPAPSLEG 900
DLGSTHWKEQ ARSGEFHAEP TVIEKEIKIP HEFHTSMKGI SSKEPRQQLV EVIGQLEETL 960
PERMREELSA LTREGQGGPG SVSVDVKKVQ GAGGSSVTLV AEVNVSQTVD ADRLDLEELS 1020
KDEASEMEKA VESVVRESLS RQRSPAPGSP DEEGGAEAPA AGIRFRRWAT RELYIPSGES 1080
EVAGGASHSS GQRTPQGPVS ATVEVSSPTG FAQSQVLEDV SQAARHIKLG PSEVWRTERM 1140
SYEGPTAEVV EVSAGGDLSQ AASPTGASRS VRHVTLGPGQ SPLSREVIFL GPAPACPEAW 1200
GSPEPGPAES SADMDGSGRH STFGCRQFHA EKEIIFQGPI SAAGKVGDYF ATEESVGTQT 1260
SVRQLQLGPK EGFSGQIQFT APLSDKVELG VIGDSVHMEG LPGSSTSIRH ISIGPQRHQT 1320
TQQIVYHGLV PQLGESGDSE STVHGEGSAD VHQATHSHTS GRQTVMTEKS TFQSVVSESP 1380
QEDSAGDTSG AEMTSGVSRS FRHIRLGPTE TETSEHIAIR GPVSRTFVLA GSADSPELGK 1440
LADSSRTLRH IAPGPKETSF TFQMDVSNVE AIRSRTQEAG ALGVSDRGSW RDADSRNDQA 1500
VGVSFKASAG EGDQAHREQG KEQAMFDKKV QLQRMVDQRS VISDEKKVAL LYLDNEEEEN 1560
DGHWF 1566
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0403--Intermediate filament
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR001664--IF
IPR018039--Intermediate_filament_CS
IPR030634--SYNM
PROSITE

PS00226--IF
Pfam

PF00038--Filament
Gene Ontology

GO:0005912--C:adherens junction
GO:0043034--C:costamere
GO:0005882--C:intermediate filament
GO:0016020--C:membrane
GO:0060053--C:neurofilament cytoskeleton
GO:0019215--F:intermediate filament binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0008307--F:structural constituent of muscle
GO:0017166--F:vinculin binding
GO:0045104--P:intermediate filament cytoskeleton organization