dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000839
Uniprot Accession O15056; SYNJ2_HUMAN; Q5TA13; Q5TA16; Q5TA19; Q86XK0; Q8IZA8; Q9H226;
Genbank Protein ID NP_001171559.1; NP_003889.1; XP_006715655.1; XP_011534527.1;
Genbank Nucleotide ID NM_001178088.1; NM_003898.3; XM_006715592.2; XM_011536225.1;
Protein Name Synaptojanin-2
Protein Synonyms/Alias Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2;
Gene Name SYNJ2
Gene Synonyms/Alias KIAA0348;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Phosphorylation Sites
 dbPAF PTMs: 38 (View all)
PositionPeptidesSourceReferences ( PMIDs )
4----MALSKGLRLLGPhosphoSitePlus22135298
61YGKLTDAYGCLGELRPhosphoSitePlus22135298
130ILSSGVFYFSWPNDGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18083107; 16381945; 23193290; 18988627; 22135298; 22817900
220RTGTRFHTRGVNDDGcurated23403867
235HVSNFVETEQMIYMDcurated23403867
240VETEQMIYMDDGVSScurated23403867
247YMDDGVSSFVQIRGScurated23403867
374FTKGENVSPRFQKGTPhosphoSitePlus22135298
490LLLVGDVYGEEVADKPhosphoSitePlus22135298
505GGMLLDSTALLVTPRcurated23403867; 24667141
616EQLQKAISRSHRYILPhosphoSitePlus22135298
618LQKAISRSHRYILLTPhosphoSitePlus22135298
825GELNLLDSDLDVDTKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18491316; 16381945; 23193290; 18988627; 22135298; 22817900
838TKVRHTWSPGALQYYPhosphoSitePlus;curated22135298; 25627689
918LRTELMQTLGSYGTIPhosphoSitePlus22135298
921ELMQTLGSYGTIVLVPhosphoSitePlus22135298
989RDSMAPVSPTANSCLcurated26074081
991SMAPVSPTANSCLLEPhosphoSitePlus22135298
994PVSPTANSCLLEENFPhosphoSitePlus22135298
1122TGLMVKKSASDASISPhosphoSitePlus;curated22135298; 22199227
Sequence
(Fasta)		MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI KGQYGKLTDA 60
YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT ATDFYPLQEE AKEEERLIAL 120
KKILSSGVFY FSWPNDGSRF DLTVRTQKQG DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW 180
LLKIICGVVT IRTVYASHKQ AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY 240
MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV 300
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE TLLRPQLKLH 360
WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI ALEVLHLQLK TLGLSSKPIV 420
DRFVESFKAM WSLNGHSLSK VFTGSRALEG KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA 480
IKLLLVGDVY GEEVADKGGM LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN 540
GGKQFRSNVL RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS 600
TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG 660
KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY KEITQKLCFP MGRNVFSHDY 720
VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL LEFDQLQLQK SSGKIFKDFH EGAINFGPTY 780
KYDVGSAAYD TSDKCRTPAW TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG 840
ALQYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT 900
LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD VDGMKVKGRA 960
VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN FDFTSLDYES EGDILEDDED 1020
YLVDEFNQPG VSDSELGGDD LSDVPGPTAL APPSKSPALT KKKQHPTYKD DADLVELKRE 1080
LEAVGEFRHR SPSRSLSVPN RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ 1140
TARLLPGAPQ QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP 1200
RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL SPEEQFEQQT 1260
VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER PSHRKPASDE APPGAGASVP 1320
PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ 1380
GDFLSTSSAT SPDSDGTKAM KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG 1440
TRSPKRDPID PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT 1497
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
Interpro

IPR015047--DUF1866
IPR005135--Endo/exonuclease/phosphatase
IPR000300--IPPc
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR002013--SAC_dom
PROSITE

PS50102--RRM
PS50275--SAC
Pfam

PF08952--DUF1866
PF03372--Exo_endo_phos
PF02383--Syja_N
Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0000166--F:nucleotide binding
GO:0004439--F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0003723--F:RNA binding
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046856--P:phosphatidylinositol dephosphorylation
GO:0006644--P:phospholipid metabolic process
GO:0006470--P:protein dephosphorylation
GO:0044281--P:small molecule metabolic process