dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000837
Uniprot Accession O15054; KDM6B_HUMAN; C9IZ40; Q96G33;
Genbank Protein ID NP_001073893.1; XP_005256606.1; XP_005256607.1; XP_005256608.1; XP_005256609.1; XP_005256611.1; XP_006721546.1; XP_011522052.1; XP_011522053.1; XP_011522054.1; XP_011522055.1;
Genbank Nucleotide ID NM_001080424.1; XM_005256549.2; XM_005256550.3; XM_005256551.2; XM_005256552.3; XM_005256554.3; XM_006721483.2; XM_011523750.1; XM_011523751.1; XM_011523752.1; XM_011523753.1;
Protein Name Lysine-specific demethylase 6B
Protein Synonyms/Alias JmjC domain-containing protein 3;Jumonji domain-containing protein 3;Lysine demethylase 6B;
Gene Name KDM6B
Gene Synonyms/Alias JMJD3;KIAA0346;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
48WLPGGRCSASIGQPPPhosphoSitePlus22135298
50PGGRCSASIGQPPLPPhosphoSitePlus22135298
218PAALSGPSGEEGLSPPhosphoSitePlus;curated22135298; 23898821
224PSGEEGLSPGGKRRRPhosphoSitePlus;curated22135298; 25850435; 25627689; 23917254; 19690332; 26074081;
380SVSPAATTACVPYAPPhosphoSitePlus22135298
400LPGTTTSSSSSSSSNPhosphoSitePlus22135298
406SSSSSSSSNTGLRGVPhosphoSitePlus22135298
589DPLPRPPSPAQNPQDcurated26074081
627GSFRRPESPRPRVSFPhosphoSitePlus22135298
637PRVSFPKTPEVGPGPPhosphoSitePlus;curated22135298; 25850435; 25627689; 23186163
705IMKMLDESIRKEEEQcurated26074081
799PPPPPPPSPASLLKScurated25627689
894EPVPGPMTPTQPPPPPhosphoSitePlus22135298
971GVAAVSGSCKRRQKEcurated25627689
1025LGNLDLQSEEIQGREPhosphoSitePlus22135298
1034EIQGREKSRPDLGGAPhosphoSitePlus22135298
1042RPDLGGASKAKPPTAPhosphoSitePlus22135298
1085APGPPGVSRADMLKLPhosphoSitePlus22135298
1524VSWNVARTVKISDPDdbPTM 3.0;PhosphoSitePlus;curated20068231; 16381945; 23193290; 22135298
1528VARTVKISDPDLFKMdbPTM 3.0;PhosphoSitePlus;curated20068231; 16381945; 23193290; 22135298
Sequence
(Fasta)		MHRAVDPPGA RAAREAFALG GLSCAGAWSS CPPHPPPRSA WLPGGRCSAS IGQPPLPAPL 60
PPSHGSSSGH PSKPYYAPGA PTPRPLHGKL ESLHGCVQAL LREPAQPGLW EQLGQLYESE 120
HDSEEATRCY HSALRYGGSF AELGPRIGRL QQAQLWNFHT GSCQHRAKVL PPLEQVWNLL 180
HLEHKRNYGA KRGGPPVKRA AEPPVVQPVP PAALSGPSGE EGLSPGGKRR RGCNSEQTGL 240
PPGLPLPPPP LPPPPPPPPP PPPPLPGLAT SPPFQLTKPG LWSTLHGDAW GPERKGSAPP 300
ERQEQRHSLP HPYPYPAPAY TAHPPGHRLV PAAPPGPGPR PPGAESHGCL PATRPPGSDL 360
RESRVQRSRM DSSVSPAATT ACVPYAPSRP PGLPGTTTSS SSSSSSNTGL RGVEPNPGIP 420
GADHYQTPAL EVSHHGRLGP SAHSSRKPFL GAPAATPHLS LPPGPSSPPP PPCPRLLRPP 480
PPPAWLKGPA CRAAREDGEI LEELFFGTEG PPRPAPPPLP HREGFLGPPA SRFSVGTQDS 540
HTPPTPPTPT TSSSNSNSGS HSSSPAGPVS FPPPPYLARS IDPLPRPPSP AQNPQDPPLV 600
PLTLALPPAP PSSCHQNTSG SFRRPESPRP RVSFPKTPEV GPGPPPGPLS KAPQPVPPGV 660
GELPARGPRL FDFPPTPLED QFEEPAEFKI LPDGLANIMK MLDESIRKEE EQQQHEAGVA 720
PQPPLKEPFA SLQSPFPTDT APTTTAPAVA VTTTTTTTTT TTATQEEEKK PPPALPPPPP 780
LAKFPPPSQP QPPPPPPPSP ASLLKSLASV LEGQKYCYRG TGAAVSTRPG PLPTTQYSPG 840
PPSGATALPP TSAAPSAQGS PQPSASSSSQ FSTSGGPWAR ERRAGEEPVP GPMTPTQPPP 900
PLSLPPARSE SEVLEEISRA CETLVERVGR SATDPADPVD TAEPADSGTE RLLPPAQAKE 960
EAGGVAAVSG SCKRRQKEHQ KEHRRHRRAC KDSVGRRPRE GRAKAKAKVP KEKSRRVLGN 1020
LDLQSEEIQG REKSRPDLGG ASKAKPPTAP APPSAPAPSA QPTPPSASVP GKKAREEAPG 1080
PPGVSRADML KLRSLSEGPP KELKIRLIKV ESGDKETFIA SEVEERRLRM ADLTISHCAA 1140
DVVRASRNAK VKGKFRESYL SPAQSVKPKI NTEEKLPREK LNPPTPSIYL ESKRDAFSPV 1200
LLQFCTDPRN PITVIRGLAG SLRLNLGLFS TKTLVEASGE HTVEVRTQVQ QPSDENWDLT 1260
GTRQIWPCES SRSHTTIAKY AQYQASSFQE SLQEEKESED EESEEPDSTT GTPPSSAPDP 1320
KNHHIIKFGT NIDLSDAKRW KPQLQELLKL PAFMRVTSTG NMLSHVGHTI LGMNTVQLYM 1380
KVPGSRTPGH QENNNFCSVN INIGPGDCEW FAVHEHYWET ISAFCDRHGV DYLTGSWWPI 1440
LDDLYASNIP VYRFVQRPGD LVWINAGTVH WVQATGWCNN IAWNVGPLTA YQYQLALERY 1500
EWNEVKNVKS IVPMIHVSWN VARTVKISDP DLFKMIKFCL LQSMKHCQVQ RESLVRAGKK 1560
IAYQGRVKDE PAYYCNECDV EVFNILFVTS ENGSRNTYLV HCEGCARRRS AGLQGVVVLE 1620
QYRTEELAQA YDAFTLAPAS TSR 1644
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0395--Inflammatory response
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR003347--JmjC_dom
IPR029518--KDM6B
PROSITE

PS51184--JMJC
Pfam

PF02373--JmjC
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0051213--F:dioxygenase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0055007--P:cardiac muscle cell differentiation
GO:0070301--P:cellular response to hydrogen peroxide
GO:0006325--P:chromatin organization
GO:0045446--P:endothelial cell differentiation
GO:0021766--P:hippocampus development
GO:0002437--P:inflammatory response to antigenic stimulus
GO:0048333--P:mesodermal cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0014823--P:response to activity
GO:0060992--P:response to fungicide