dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000831
Uniprot Accession O15040; TCPR2_HUMAN; A5PKY3; A6NFY9; A7E2X3; H0YMM9; Q9UEG6;
Genbank Protein ID NP_001166102.1; NP_055659.2;
Genbank Nucleotide ID NM_001172631.2; NM_014844.4;
Protein Name Tectonin beta-propeller repeat-containing protein 2
Protein Synonyms/Alias WD repeat-containing protein KIAA0329/KIAA0297;
Gene Name TECPR2
Gene Synonyms/Alias KIAA0297;KIAA0329;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Probably plays a role as positive regulator of autophagy.
Phosphorylation Sites
 dbPAF PTMs: 27 (View all)
PositionPeptidesSourceReferences ( PMIDs )
33KIQKGFRSIVVYLTAcurated23403867
37GFRSIVVYLTALDTNPhosphoSitePlus22135298
39RSIVVYLTALDTNGDcurated23403867
43VYLTALDTNGDYIAVcurated23403867
47ALDTNGDYIAVGSSIPhosphoSitePlus22135298
58GSSIGMLYLYCRHLNPhosphoSitePlus22135298
60SIGMLYLYCRHLNQMPhosphoSitePlus22135298
188SQKVLLVSTLQRSLLcurated26074081
193LVSTLQRSLLFYTEEcurated26074081
208KSVRQIGTQPRKSTGcurated23898821
276ELHPRLESPNSGSCSPhosphoSitePlus;curated22135298; 25627689
401RGSSMASSVASEPRSPhosphoSitePlus22135298
404SMASSVASEPRSRSSPhosphoSitePlus22135298
410ASEPRSRSSSLNSTDPhosphoSitePlus22135298
412EPRSRSSSLNSTDSGPhosphoSitePlus22135298
418SSLNSTDSGSGLLPPPhosphoSitePlus22135298
448SQRFNAISSEDFDQEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20363803; 22115753; 18988627;
449QRFNAISSEDFDQELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20363803; 22115753; 18988627;
472RKKKKKKTEGGSRSTPhosphoSitePlus22135298
486TCHSSLESTPCSEFPPhosphoSitePlus22135298
Sequence
(Fasta)		MASISEPVTF REFCPLYYLL NAIPTKIQKG FRSIVVYLTA LDTNGDYIAV GSSIGMLYLY 60
CRHLNQMRKY NFEGKTESIT VVKLLSCFDD LVAAGTASGR VAVFQLVSSL PGRNKQLRRF 120
DVTGIHKNSI TALAWSPNGM KLFSGDDKGK IVYSSLDLDQ GLCNSQLVLE EPSSIVQLDY 180
SQKVLLVSTL QRSLLFYTEE KSVRQIGTQP RKSTGKFGAC FIPGLCKQSD LTLYASRPGL 240
RLWKADVHGT VQATFILKDA FAGGVKPFEL HPRLESPNSG SCSLPERHLG LVSCFFQEGW 300
VLSWNEYSIY LLDTVNQATV AGLEGSGDIV SVSCTENEIF FLKGDRNIIR ISSRPEGLTS 360
TVRDGLEMSG CSERVHVQQA EKLPGATVSE TRLRGSSMAS SVASEPRSRS SSLNSTDSGS 420
GLLPPGLQAT PELGKGSQPL SQRFNAISSE DFDQELVVKP IKVKRKKKKK KTEGGSRSTC 480
HSSLESTPCS EFPGDSPQSL NTDLLSMTSS VLGSSVDQLS AESPDQESSF NGEVNGVPQE 540
NTDPETFNVL EVSGSMPDSL AEEDDIRTEM PHCHHAHGRE LLNGAREDVG GSDVTGLGDE 600
PCPADDGPNS TQLPFQEQDS SPGAHDGEDI QPIGPQSTFC EVPLLNSLTV PSSLSWAPSA 660
EQWLPGTRAD EGSPVEPSQE QDILTSMEAS GHLSTNLWHA VTDDDTGQKE IPISERVLGS 720
VGGQLTPVSA LAASTHKPWL EQPPRDQTLT SSDEEDIYAH GLPSSSSETS VTELGPSCSQ 780
QDLSRLGAED AGLLKPDQFA ESWMGYSGPG YGILSLVVSE KYIWCLDYKG GLFCSALPGA 840
GLRWQKFEDA VQQVAVSPSG ALLWKIEQKS NRAFACGKVT IKGKRHWYEA LPQAVFVALS 900
DDTAWIIRTS GDLYLQTGLS VDRPCARAVK VDCPYPLSQI TARNNVVWAL TEQRALLYRE 960
GVSSFCPEGE QWKCDIVSER QALEPVCITL GDQQTLWALD IHGNLWFRTG IISKKPQGDD 1020
DHWWQVSITD YVVFDQCSLF QTIIHATHSV ATAAQAPVEK VADKLRMAFW SQQLQCQPSL 1080
LGVNNSGVWI SSGKNEFHVA KGSLIGTYWN HVVPRGTASA TKWAFVLASA APTKEGSFLW 1140
LCQSSKDLCS VSAQSAQSRP STVQLPPEAE MRAYAACQDA LWALDSLGQV FIRTLSKSCP 1200
TGMHWTRLDL SQLGAVKLTS LACGNQHIWA CDSRGGVYFR VGTQPLNPSL MLPAWIMIEP 1260
PVQPAGVSLV SVHSSPNDQM LWVLDSRWNV HVRTGITEEM PVGTAWEHVP GLQACQLALS 1320
TRTVWARCPN GDLARRYGVT DKNPAGDYWK KIPGSVSCFT VTASDELWAV GPPGYLLQRL 1380
TKTFSHSHGT QKSSQAAMPH PEDLEDEWEV I 1412
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0890--Hereditary spastic paraplegia
KW-0523--Neurodegeneration
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR006624--Beta-propeller_rpt_TECPR
IPR009091--RCC1/BLIP-II
IPR029772--TECPR2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE
Pfam

PF06462--Hyd_WA
Gene Ontology

GO:0006914--P:autophagy