dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000829
Uniprot Accession O15034; RIMB2_HUMAN; Q96ID2;
Genbank Protein ID NP_056162.4;
Genbank Nucleotide ID NM_015347.4;
Protein Name RIMS-binding protein 2
Protein Synonyms/Alias
Gene Name RIMBP2
Gene Synonyms/Alias KIAA0318;RBP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
99FMNGLATSLGKGQEScurated25348772
376QCVTSRGSSDELQCTPhosphoSitePlus22135298
377CVTSRGSSDELQCTLPhosphoSitePlus22135298
628MDEAWEQSRAPGPVHPhosphoSitePlus22135298
690SSRLEKRSVFLERSSPhosphoSitePlus22135298
696RSVFLERSSAGQYAAPhosphoSitePlus22135298
697SVFLERSSAGQYAASPhosphoSitePlus22135298
704SAGQYAASDEEDAYDPhosphoSitePlus22135298
710ASDEEDAYDSPDFKRPhosphoSitePlus22135298
745CHGDEYHTESSRGSDPhosphoSitePlus22135298
747GDEYHTESSRGSDLSPhosphoSitePlus22135298
748DEYHTESSRGSDLSDPhosphoSitePlus22135298
Sequence
(Fasta)		MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ FNLLSRDLEK 60
FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL GKGQESAIGG SSAIGEYIRP 120
LPQPGDRPEP LSAKPTFLSR SGSARCRSES DMENERNSNT SKQRYSGKVH LCVARYSYNP 180
FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA 240
STLGNEQDQN FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP 300
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT KALIEKLNMA 360
ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD NITQISAQLS WLPTNSNYSH 420
VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS 480
TLPAGPPAPP QDVTVQAGVT PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI 540
FPTADSTAVE LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK 600
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP SPSRILPQPQ 660
GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ YAASDEEDAY DSPDFKRRGA 720
SVDDFLKGSE LGKQPHCCHG DEYHTESSRG SDLSDIMEED EEELYSEMQL EDGGRRRPSG 780
TSHNALKILG NPASAGRVDH MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE 840
TDPGAEELPA RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC 900
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH SVSTRRMVAL 960
YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG ELNGQKGLVP SNFLEEVPDD 1020
VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF TP 1053
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0770--Synapse
KW-0832--Ubl conjugation
Interpro

IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50853--FN3
PS50002--SH3
Pfam

PF07653--SH3_2
PF14604--SH3_9
Gene Ontology

GO:0030054--C:cell junction
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0010923--P:negative regulation of phosphatase activity