dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000828
Uniprot Accession O15033; AREL1_HUMAN; B4E2C7; Q7LDY1; Q8IYY9;
Genbank Protein ID NP_001034568.1; XP_011535717.1;
Genbank Nucleotide ID NM_001039479.1; XM_011537415.1;
Protein Name Apoptosis-resistant E3 ubiquitin protein ligase 1
Protein Synonyms/Alias
Gene Name AREL1
Gene Synonyms/Alias KIAA0317;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
47RRGDRTIYDYVRGNYPhosphoSitePlus22135298
84AFRVHLFYKNGQPFPPhosphoSitePlus22135298
327TSSQRRPSTAVDEEDPhosphoSitePlus;curated22135298; 25850435; 25849741; 24961811
328SSQRRPSTAVDEEDEPhosphoSitePlus;curated22135298; 22817900; 24961811
337VDEEDEDSPSECHTPPhosphoSitePlus;curated22135298; 25850435; 22817900
339EEDEDSPSECHTPEKcurated25850435; 24961811
343DSPSECHTPEKVKKPPhosphoSitePlus;curated22135298; 23898821; 22817900
356KPKKVYCYVSPKQFSPhosphoSitePlus22135298
368QFSVKEFYLKIIPWRPhosphoSitePlus;curated22135298; 23186163
436LHKNIGGSETFQDKVPhosphoSitePlus22135298
564RLVGKCLYESSLGGAPhosphoSitePlus22135298
566VGKCLYESSLGGAYKPhosphoSitePlus22135298
567GKCLYESSLGGAYKQPhosphoSitePlus22135298
572ESSLGGAYKQLVRARPhosphoSitePlus22135298
Sequence
(Fasta)		MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120
PNSNVVKVAF TVRKAGRYEI TVKLGGLNVA YSPYYKIFQP GMVVPSKTKI VCHFSTLVLT 180
CGQPHTLQIV PRDEYDNPTN NSMSLRDEHN YTLSIHELGP QEEESTGVSF EKSVTSNRQT 240
FQVFLRLTLH SRGCFHACIS YQNQPINNGE FDIIVLSEDE KNIVERNVST SGVSIYFEAY 300
LYNATNCSST PWHLPPMHMT SSQRRPSTAV DEEDEDSPSE CHTPEKVKKP KKVYCYVSPK 360
QFSVKEFYLK IIPWRLYTFR VCPGTKFSYL GPDPVHKLLT LVVDDGIQPP VELSCKERNI 420
LAATFIRSLH KNIGGSETFQ DKVNFFQREL RQVHMKRPHS KVTLKVSRHA LLESSLKATR 480
NFSISDWSKN FEVVFQDEEA LDWGGPRREW FELICKALFD TTNQLFTRFS DNNQALVHPN 540
PNRPAHLRLK MYEFAGRLVG KCLYESSLGG AYKQLVRARF TRSFLAQIIG LRMHYKYFET 600
DDPEFYKSKV CFILNNDMSE MELVFAEEKY NKSGQLDKVV ELMTGGAQTP VTNANKIFYL 660
NLLAQYRLAS QVKEEVEHFL KGLNELVPEN LLAIFDENEL ELLMCGTGDI SVSDFKAHAV 720
VVGGSWHFRE KVMRWFWTVV SSLTQEELAR LLQFTTGSSQ LPPGGFAALC PSFQIIAAPT 780
HSTLPTAHTC FNQLCLPTYD SYEEVHRMLQ LAISEGCEGF GML 824
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT
Pfam

PF00630--Filamin
PF00632--HECT
Gene Ontology

GO:0005829--C:cytosol
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process