dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000827
Uniprot Accession O15031; PLXB2_HUMAN; A6QRH0; Q7KZU3; Q9BSU7;
Genbank Protein ID NP_036533.2; XP_005261966.1; XP_005261967.1; XP_005261968.1; XP_006724476.1; XP_011528985.1;
Genbank Nucleotide ID NM_012401.3; XM_005261909.1; XM_005261910.1; XM_005261911.3; XM_006724413.1; XM_011530683.1;
Protein Name Plexin-B2
Protein Synonyms/Alias MM1;
Gene Name PLXNB2
Gene Synonyms/Alias KIAA0315;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
126ICALRALSNISLRLFPhosphoSitePlus22135298
419DGRILKVYLTPDGTSPhosphoSitePlus22135298
452VLSGDLGSLYAMTQDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
1124TNLNKAMTLQEAEAFdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
1224VYCYWRKSQQAEREYPhosphoSitePlus22135298
1231SQQAEREYEKIKSQLPhosphoSitePlus22135298
1244QLEGLEESVRDRCKKPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 23186163; 24961811
1320EQALYQFSNLLNSKSPhosphoSitePlus22135298
1325QFSNLLNSKSFLINFPhosphoSitePlus22135298
1327SNLLNSKSFLINFIHPhosphoSitePlus22135298
1349FSARAKVYFASLLTVPhosphoSitePlus22135298
1410NWMSICLYQYLKDSAPhosphoSitePlus22135298
1412MSICLYQYLKDSAGEPhosphoSitePlus22135298
1422DSAGEPLYKLFKAIKPhosphoSitePlus22135298
1499EKIIDQVYRGQPCSCPhosphoSitePlus22135298
1570VSQQPEDSQQDLPGEdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 25627689; 22817900;
1614SVKEKERTKAITEIYPhosphoSitePlus22135298
1621TKAITEIYLTRLLSVPhosphoSitePlus22135298
1623AITEIYLTRLLSVKGPhosphoSitePlus22135298
1627IYLTRLLSVKGTLQQPhosphoSitePlus22135298
Sequence
(Fasta)		MALQLWALTL LGLLGAGASL RPRKLDFFRS EKELNHLAVD EASGVVYLGA VNALYQLDAK 60
LQLEQQVATG PALDNKKCTP PIEASQCHEA EMTDNVNQLL LLDPPRKRLV ECGSLFKGIC 120
ALRALSNISL RLFYEDGSGE KSFVASNDEG VATVGLVSST GPGGDRVLFV GKGNGPHDNG 180
IIVSTRLLDR TDSREAFEAY TDHATYKAGY LSTNTQQFVA AFEDGPYVFF VFNQQDKHPA 240
RNRTLLARMC REDPNYYSYL EMDLQCRDPD IHAAAFGTCL AASVAAPGSG RVLYAVFSRD 300
SRSSGGPGAG LCLFPLDKVH AKMEANRNAC YTGTREARDI FYKPFHGDIQ CGGHAPGSSK 360
SFPCGSEHLP YPLGSRDGLR GTAVLQRGGL NLTAVTVAAE NNHTVAFLGT SDGRILKVYL 420
TPDGTSSEYD SILVEINKRV KRDLVLSGDL GSLYAMTQDK VFRLPVQECL SYPTCTQCRD 480
SQDPYCGWCV VEGRCTRKAE CPRAEEASHW LWSRSKSCVA VTSAQPQNMS RRAQGEVQLT 540
VSPLPALSEE DELLCLFGES PPHPARVEGE AVICNSPSSI PVTPPGQDHV AVTIQLLLRR 600
GNIFLTSYQY PFYDCRQAMS LEENLPCISC VSNRWTCQWD LRYHECREAS PNPEDGIVRA 660
HMEDSCPQFL GPSPLVIPMN HETDVNFQGK NLDTVKGSSL HVGSDLLKFM EPVTMQESGT 720
FAFRTPKLSH DANETLPLHL YVKSYGKNID SKLHVTLYNC SFGRSDCSLC RAANPDYRCA 780
WCGGQSRCVY EALCNTTSEC PPPVITRIQP ETGPLGGGIR ITILGSNLGV QAGDIQRISV 840
AGRNCSFQPE RYSVSTRIVC VIEAAETPFT GGVEVDVFGK LGRSPPNVQF TFQQPKPLSV 900
EPQQGPQAGG TTLTIHGTHL DTGSQEDVRV TLNGVPCKVT KFGAQLQCVT GPQATRGQML 960
LEVSYGGSPV PNPGIFFTYR ENPVLRAFEP LRSFASGGRS INVTGQGFSL IQRFAMVVIA 1020
EPLQSWQPPR EAESLQPMTV VGTDYVFHND TKVVFLSPAV PEEPEAYNLT VLIEMDGHRA 1080
LLRTEAGAFE YVPDPTFENF TGGVKKQVNK LIHARGTNLN KAMTLQEAEA FVGAERCTMK 1140
TLTETDLYCE PPEVQPPPKR RQKRDTTHNL PEFIVKFGSR EWVLGRVEYD TRVSDVPLSL 1200
ILPLVIVPMV VVIAVSVYCY WRKSQQAERE YEKIKSQLEG LEESVRDRCK KEFTDLMIEM 1260
EDQTNDVHEA GIPVLDYKTY TDRVFFLPSK DGDKDVMITG KLDIPEPRRP VVEQALYQFS 1320
NLLNSKSFLI NFIHTLENQR EFSARAKVYF ASLLTVALHG KLEYYTDIMH TLFLELLEQY 1380
VVAKNPKLML RRSETVVERM LSNWMSICLY QYLKDSAGEP LYKLFKAIKH QVEKGPVDAV 1440
QKKAKYTLND TGLLGDDVEY APLTVSVIVQ DEGVDAIPVK VLNCDTISQV KEKIIDQVYR 1500
GQPCSCWPRP DSVVLEWRPG STAQILSDLD LTSQREGRWK RVNTLMHYNV RDGATLILSK 1560
VGVSQQPEDS QQDLPGERHA LLEEENRVWH LVRPTDEVDE GKSKRGSVKE KERTKAITEI 1620
YLTRLLSVKG TLQQFVDNFF QSVLAPGHAV PPAVKYFFDF LDEQAEKHNI QDEDTIHIWK 1680
TNSLPLRFWV NILKNPHFIF DVHVHEVVDA SLSVIAQTFM DACTRTEHKL SRDSPSNKLL 1740
YAKEISTYKK MVEDYYKGIR QMVQVSDQDM NTHLAEISRA HTDSLNTLVA LHQLYQYTQK 1800
YYDEIINALE EDPAAQKMQL AFRLQQIAAA LENKVTDL 1839
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR002909--IPT
IPR031148--Plexin
IPR016201--Plexin-like_fold
IPR013548--Plexin_cytoplasmic_RasGAP_dom
IPR002165--Plexin_repeat
IPR001936--RasGAP_dom
IPR008936--Rho_GTPase_activation_prot
IPR001627--Semap_dom
IPR015943--WD40/YVTN_repeat-like_dom
PROSITE

PS51004--SEMA
Pfam

PF08337--Plexin_cytopl
PF01437--PSI
PF01403--Sema
PF01833--TIG
Gene Ontology

GO:0009986--C:cell surface
GO:0070062--C:extracellular exosome
GO:0005887--C:integral component of plasma membrane
GO:0002116--C:semaphorin receptor complex
GO:0017154--F:semaphorin receptor activity
GO:0007420--P:brain development
GO:0007162--P:negative regulation of cell adhesion
GO:0001843--P:neural tube closure
GO:0007405--P:neuroblast proliferation
GO:0050772--P:positive regulation of axonogenesis
GO:0030334--P:regulation of cell migration
GO:0008360--P:regulation of cell shape
GO:0043087--P:regulation of GTPase activity
GO:2001222--P:regulation of neuron migration
GO:0001932--P:regulation of protein phosphorylation
GO:0071526--P:semaphorin-plexin signaling pathway
GO:1902287--P:semaphorin-plexin signaling pathway involved in axon guidance