dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000826
Uniprot Accession O15027; SC16A_HUMAN; A1YCA4; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1;
Genbank Protein ID NP_001263347.1; NP_055681.1; XP_011517554.1;
Genbank Nucleotide ID NM_001276418.1; NM_014866.1; XM_011519252.1;
Protein Name Protein transport protein Sec16A
Protein Synonyms/Alias SEC16 homolog A;
Gene Name SEC16A
Gene Synonyms/Alias KIAA0310;SEC16;SEC16L;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.
Phosphorylation Sites
 dbPAF PTMs: 161 (View all)
PositionPeptidesSourceReferences ( PMIDs )
9PGLDRPLSRQNPHDGPhosphoSitePlus22135298
19NPHDGVVTPAASPSLHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298; 23898821; 26074081
23GVVTPAASPSLPQPGHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298; 23898821; 26074081
110DEVSHLQSGSHLANNPhosphoSitePlus22135298
112VSHLQSGSHLANNSDPhosphoSitePlus22135298
118GSHLANNSDPESTFRPhosphoSitePlus;UniProt;curated22135298; 24275569; 25850435; 23663014
122ANNSDPESTFRQNPRdbPTM 3.020068231; 16381945; 23193290
136RIVNHWASPELRQNPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 17924679; 18669648; 18691976; 16381945; 23193290;
153KNEHRPASALVNPLAPhosphoSitePlus;curated22135298; 25850435; 25627689; 20873877; 24961811
164NPLARGDSPENRTHHPhosphoSitePlus;curated22135298; 25627689; 26074081
169GDSPENRTHHPLGAGcurated26074081
179PLGAGAGSGCAPLEAdbPTM 3.018669648; 16381945; 23193290
227ADFDDFCSSPGLGRPPhosphoSitePlus22135298
304PLNLDPSSPSDQFRYPhosphoSitePlus22135298
311SPSDQFRYGPLPGPAPhosphoSitePlus22135298
345VHPDSVSSSYSSRSHPhosphoSitePlus22135298
346HPDSVSSSYSSRSHGPhosphoSitePlus22135298
347PDSVSSSYSSRSHGRPhosphoSitePlus22135298
348DSVSSSYSSRSHGRLPhosphoSitePlus22135298
349SVSSSYSSRSHGRLSPhosphoSitePlus22135298
Sequence
(Fasta)		MPGLDRPLSR QNPHDGVVTP AASPSLPQPG LQMPGQWGPV QGGPQPSGQH RSPCPEGPVP 60
SGVPCATSVP HFPTPSILHQ GPGHEQHSPL VAPPAALPSD GRDEVSHLQS GSHLANNSDP 120
ESTFRQNPRI VNHWASPELR QNPGVKNEHR PASALVNPLA RGDSPENRTH HPLGAGAGSG 180
CAPLEADSGA SGALAMFFQG GETENEENLS SEKAGLSGQA DFDDFCSSPG LGRPPAPTHV 240
GAGSLCQALL PGPSNEAAGD VWGDTASTGV PDASGSQYEN VENLEFVQNQ EVLPSEPLNL 300
DPSSPSDQFR YGPLPGPAVP RHGAVCHTGA PDATLHTVHP DSVSSSYSSR SHGRLSGSAR 360
PQELVGTFIQ QEVGKPEDEA SGSFFKQIDS SPVGGETDET TVSQNYRGSV SQPSTPSPPK 420
PTGIFQTSAN SSFEPVKSHL VGVKPFEADR ANVVGEVRET CVRQKQCRPA AALPDASPGN 480
LEQPPDNMET LCAPQVCPLP LNSTTEAVHM LPHAGAPPLD TVYPAPEKRP SARTQGPVKC 540
ESPATTLWAQ SELPDFGGNV LLAPAAPALY VCAKPQPPVV QPPEEAMSGQ QSRNPSSAAP 600
VQSRGGIGAS ENLENPPKMG EEEALQSQAS SGYASLLSSP PTESLQNPPV LIAQPDHSYN 660
LAQPINFSVS LSNSHEKNQS WREALVGDRP AVSSWALGGD SGENTSLSGI PTSSVLSLSL 720
PSSVAQSNFP QGSGASEMVS NQPANLLVQP PSQPVPENLV PESQKDRKAG SALPGFANSP 780
AGSTSVVLVP PAHGTLVPDG NKANHSSHQE DTYGALDFTL SRTLENPVNV YNPSHSDSLA 840
SQQSVASHPR QSGPGAPNLD RFYQQVTKDA QGQPGLERAQ QELVPPQQQA SPPQLPKAMF 900
SELSNPESLP AQGQAQNSAQ SPASLVLVDA GQQLPPRPPQ SSSVSLVSSG SGQAAVPSEQ 960
PWPQPVPALA PGPPPQDLAA YYYYRPLYDA YQPQYSLPYP PEPGAASLYY QDVYSLYEPR 1020
YRPYDGAASA YAQNYRYPEP ERPSSRASHS SERPPPRQGY PEGYYSSKSG WSSQSDYYAS 1080
YYSSQYDYGD PGHWDRYHYS ARVRDPRTYD RRYWCDAEYD AYRREHSAFG DRPEKRDNNW 1140
RYDPRFTGSF DDDPDPHRDP YGEEVDRRSV HSEHSARSLH SAHSLASRRS SLSSHSHQSQ 1200
IYRSHNVAAG SYEAPLPPGS FHGDFAYGTY RSNFSSGPGF PEYGYPADTV WPAMEQVSSR 1260
PTSPEKFSVP HVCARFGPGG QLIKVIPNLP SEGQPALVEV HSMEALLQHT SEQEEMRAFP 1320
GPLAKDDTHK VDVINFAQNK AMKCLQNENL IDKESASLLW NFIVLLCRQN GTVVGTDIAE 1380
LLLRDHRTVW LPGKSPNEAN LIDFTNEAVE QVEEEESGEA QLSFLTGGPA AAASSLERET 1440
ERFRELLLYG RKKDALESAM KNGLWGHALL LASKMDSRTH ARVMTRFANS LPINDPLQTV 1500
YQLMSGRMPA ASTCCGDEKW GDWRPHLAMV LSNLNNNMDV ESRTMATMGD TLASRGLLDA 1560
AHFCYLMAQA GFGVYTKKTT KLVLIGSNHS LPFLKFATNE AIQRTEAYEY AQSLGAETCP 1620
LPSFQVFKFI YSCRLAEMGL ATQAFHYCEA IAKSILTQPH LYSPVLISQL VQMASQLRLF 1680
DPQLKEKPEE ESLAAPTWLV HLQQVERQIK EGAGVWHQDG ALPQQCPGTP SSEMEQLDRP 1740
GLSQPGALGI ANPLLAVPAP SPEHSSPSVR LLPSAPQTLP DGPLASPARV PMFPVPLPPG 1800
PLEPGPGCVT PGPALGFLEP SGPGLPPGVP PLQERRHLLQ EARSPDPGIV PQEAPVGNSL 1860
SELSEENFDG KFANLTPSRT VPDSEAPPGW DRADSGPTQP PLSLSPAPET KRPGQAAKKE 1920
TKEPKKGESW FFRWLPGKKK TEAYLPDDKN KSIVWDEKKN QWVNLNEPEE EKKAPPPPPT 1980
SMPKTVQAAP PALPGPPGAP VNMYSRRAAG TRARYVDVLN PSGTQRSEPA LAPADFVAPL 2040
APLPIPSNLF VPTPDAEEPQ LPDGTGREGP AAARGLANPE PAPEPKVLSS AASLPGSELP 2100
SSRPEGSQGG ELSRCSSMSS LSREVSQHFN QAPGDLPAAG GPPSGAMPFY NPAQLAQACA 2160
TSGSSRLGRI GQRKHLVLN
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR024298--ACE1_Sec16_Sec31
IPR024880--Sec16
IPR024340--Sec16_CCD
PROSITE
Pfam

PF12932--Sec16
PF12931--Sec16_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0044267--P:cellular protein metabolic process
GO:0048208--P:COPII vesicle coating
GO:0007029--P:endoplasmic reticulum organization
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0061024--P:membrane organization
GO:0043687--P:post-translational protein modification
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0015031--P:protein transport
GO:0021762--P:substantia nigra development