dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000825
Uniprot Accession O15021; MAST4_HUMAN; A6NL49; B5ME48; Q05EE6; Q6ZN07; Q8N4X4; Q96LY3;
Genbank Protein ID NP_001277155.1; NP_001277157.1; NP_001284580.1; NP_055998.1; NP_942123.1; XP_006714669.1;
Genbank Nucleotide ID NM_001290226.1; NM_001290228.1; NM_001297651.1; NM_015183.2; NM_198828.2; XM_006714606.2;
Protein Name Microtubule-associated serine/threonine-protein kinase 4
Protein Synonyms/Alias
Gene Name MAST4
Gene Synonyms/Alias KIAA0303;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 105 (View all)
PositionPeptidesSourceReferences ( PMIDs )
32ASALVAASSPGASSAPhosphoSitePlus22135298
114APRGSSASQEEQDEEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18988627; 22135298; 22817900
137PMPFRKCSNPDVASGcurated25849741
166GRQLRRGSLGGALTGPhosphoSitePlus;curated22135298; 25849741
206RSQALGQSAPSLTASPhosphoSitePlus;curated22135298; 25849741
211GQSAPSLTASLKELSPhosphoSitePlus;curated22135298; 24667141
218TASLKELSLPRRGSLcurated23186163
248PALPRPHSPLSAHAGcurated23898821
257LSAHAGNSPQDSPRNcurated23898821
266QDSPRNFSPSASAHFPhosphoSitePlus;curated22135298; 23898821
268SPRNFSPSASAHFSFPhosphoSitePlus;curated22135298; 23186163
270RNFSPSASAHFSFARPhosphoSitePlus;curated22135298; 23917254
288RTDGRRWSLASLPSSdbPTM 3.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 22135298; 23917254; 22817900
291GRRWSLASLPSSGYGPhosphoSitePlus22135298
301SSGYGTNTPSSTVSSPhosphoSitePlus22135298
304YGTNTPSSTVSSSCScurated23090842
308TPSSTVSSSCSSQEKcurated23090842
311STVSSSCSSQEKLHQcurated23090842
356NTPMRPRSRSLSPGRPhosphoSitePlus;curated22135298; 23898821
358PMRPRSRSLSPGRSPdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated19369195; 20068231; 16381945; 23193290; 21081558; 22135298;
Sequence
(Fasta)		MGEKVSEAPE PVPRGCSGHG SRTPASALVA ASSPGASSAE SSSGSETLSE EGEPGGFSRE 60
HQPPPPPPLG GTLGARAPAA WAPASVLLER GVLALPPPLP GGAVPPAPRG SSASQEEQDE 120
ELDHILSPPP MPFRKCSNPD VASGPGKSLK YKRQLSEDGR QLRRGSLGGA LTGRYLLPNP 180
VAGQAWPASA ETSNLVRMRS QALGQSAPSL TASLKELSLP RRGSLCRTSN RKSLIGNGQS 240
PALPRPHSPL SAHAGNSPQD SPRNFSPSAS AHFSFARSLN RTDGRRWSLA SLPSSGYGTN 300
TPSSTVSSSC SSQEKLHQLP YQPTPDELHF LSKHFCTTES IATENRCRNT PMRPRSRSLS 360
PGRSPACCDH EIIMMNHVYK ERFPKATAQM EERLKEIITS YSPDNVLPLA DGVLSFTHHQ 420
IIELARDCLD KSHQGLITSR YFLELQHKLD KLLQEAHDRS ESGELAFIKQ LVRKILIVIA 480
RPARLLECLE FDPEEFYYLL EAAEGHAKEG QGIKTDIPRY IISQLGLNKD PLEEMAHLGN 540
YDSGTAETPE TDESVSSSNA SLKLRRKPRE SDFETIKLIS NGAYGAVYFV RHKESRQRFA 600
MKKINKQNLI LRNQIQQAFV ERDILTFAEN PFVVSMYCSF ETRRHLCMVM EYVEGGDCAT 660
LMKNMGPLPV DMARMYFAET VLALEYLHNY GIVHRDLKPD NLLVTSMGHI KLTDFGLSKV 720
GLMSMTTNLY EGHIEKDARE FLDKQVCGTP EYIAPEVILR QGYGKPVDWW AMGIILYEFL 780
VGCVPFFGDT PEELFGQVIS DEINWPEKDE APPPDAQDLI TLLLRQNPLE RLGTGGAYEV 840
KQHRFFRSLD WNSLLRQKAE FIPQLESEDD TSYFDTRSEK YHHMETEEED DTNDEDFNVE 900
IRQFSSCSHR FSKVFSSIDR ITQNSAEEKE DSVDKTKSTT LPSTETLSWS SEYSEMQQLS 960
TSNSSDTESN RHKLSSGLLP KLAISTEGEQ DEAASCPGDP HEEPGKPALP PEECAQEEPE 1020
VTTPASTISS STLSVGSFSE HLDQINGRSE CVDSTDNSSK PSSEPASHMA RQRLESTEKK 1080
KISGKVTKSL SASALSLMIP GDMFAVSPLG SPMSPHSLSS DPSSSRDSSP SRDSSAASAS 1140
PHQPIVIHSS GKNYGFTIRA IRVYVGDSDI YTVHHIVWNV EEGSPACQAG LKAGDLITHI 1200
NGEPVHGLVH TEVIELLLKS GNKVSITTTP FENTSIKTGP ARRNSYKSRM VRRSKKSKKK 1260
ESLERRRSLF KKLAKQPSPL LHTSRSFSCL NRSLSSGESL PGSPTHSLSP RSPTPSYRST 1320
PDFPSGTNSS QSSSPSSSAP NSPAGSGHIR PSTLHGLAPK LGGQRYRSGR RKSAGNIPLS 1380
PLARTPSPTP QPTSPQRSPS PLLGHSLGNS KIAQAFPSKM HSPPTIVRHI VRPKSAEPPR 1440
SPLLKRVQSE EKLSPSYGSD KKHLCSRKHS LEVTQEEVQR EQSQREAPLQ SLDENVCDVP 1500
PLSRARPVEQ GCLKRPVSRK VGRQESVDDL DRDKLKAKVV VKKADGFPEK QESHQKSHGP 1560
GSDLENFALF KLEEREKKVY PKAVERSSTF ENKASMQEAP PLGSLLKDAL HKQASVRASE 1620
GAMSDGRVPA EHRQGGGDFR RAPAPGTLQD GLCHSLDRGI SGKGEGTEKS SQAKELLRCE 1680
KLDSKLANID YLRKKMSLED KEDNLCPVLK PKMTAGSHEC LPGNPVRPTG GQQEPPPASE 1740
SRAFVSSTHA AQMSAVSFVP LKALTGRVDS GTEKPGLVAP ESPVRKSPSE YKLEGRSVSC 1800
LKPIEGTLDI ALLSGPQASK TELPSPESAQ SPSPSGDVRA SVPPVLPSSS GKKNDTTSAR 1860
ELSPSSLKMN KSYLLEPWFL PPSRGLQNSP AVSLPDPEFK RDRKGPHPTA RSPGTVMESN 1920
PQQREGSSPK HQDHTTDPKL LTCLGQNLHS PDLARPRCPL PPEASPSREK PGLRESSERG 1980
PPTARSERSA ARADTCREPS MELCFPETAK TSDNSKNLLS VGRTHPDFYT QTQAMEKAWA 2040
PGGKTNHKDG PGEARPPPRD NSSLHSAGIP CEKELGKVRR GVEPKPEALL ARRSLQPPGI 2100
ESEKSEKLSS FPSLQKDGAK EPERKEQPLQ RHPSSIPPPP LTAKDLSSPA ARQHCSSPSH 2160
ASGREPGAKP STAEPSSSPQ DPPKPVAAHS ESSSHKPRPG PDPGPPKTKH PDRSLSSQKP 2220
SVGATKGKEP ATQSLGGSSR EGKGHSKSGP DVFPATPGSQ NKASDGIGQG EGGPSVPLHT 2280
DRAPLDAKPQ PTSGGRPLEV LEKPVHLPRP GHPGPSEPAD QKLSAVGEKQ TLSPKHPKPS 2340
TVKDCPTLCK QTDNRQTDKS PSQPAANTDR RAEGKKCTEA LYAPAEGDKL EAGLSFVHSE 2400
NRLKGAERPA AGVGKGFPEA RGKGPGPQKP PTEADKPNGM KRSPSATGQS SFRSTALPEK 2460
SLSCSSSFPE TRAGVREASA ASSDTSSAKA AGGMLELPAP SNRDHRKAQP AGEGRTHMTK 2520
SDSLPSFRVS TLPLESHHPD PNTMGGASHR DRALSVTATV GETKGKDPAP AQPPPARKQN 2580
VGRDVTKPSP APNTDRPISL SNEKDFVVRQ RRGKESLRSS PHKKAL 2627
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR015022--MA_Ser/Thr_Kinase_dom
IPR023142--MAST_pre-PK_dom
IPR001478--PDZ
IPR000719--Prot_kinase_dom
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS50106--PDZ
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF08926--DUF1908
PF00595--PDZ
PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005622--C:intracellular
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0035556--P:intracellular signal transduction
GO:0018105--P:peptidyl-serine phosphorylation