dbPAF - database of Phospho-sites in Animals and Fungi

Protein
Gene
PTMs
Sequence
Keyword
GO
TOP

dbPAF Protein Information

Tag

Content

dbPAF ID

dbPAF-0000824

Uniprot Accession

O15020; SPTN2_HUMAN; O14872; O14873;

Genbank Protein ID

NP_008877.1; XP_005274249.1; XP_005274250.1; XP_006718734.1;

Genbank Nucleotide ID

NM_006946.2; XM_005274192.3; XM_005274193.3; XM_006718671.2;

Protein Name

Spectrin beta chain, non-erythrocytic 2

Protein Synonyms/Alias

Beta-III spectrin;Spinocerebellar ataxia 5 protein;

Gene Name

SPTBN2

Gene Synonyms/Alias

KIAA0302;SCA5;

Organism

Homo sapiens(Human)

NCBI Taxa ID

9606

Functional Description
(View all)

Probably plays an important role in neuronal membrane skeleton.

Phosphorylation Sites

dbPAF PTMs: 39 (View all)

Position	Peptides	Source	References ( PMIDs )
6	--MSSTLSPTDFDSL	dbPTM 3.0;HPRD 9;curated	20068231; 16381945; 23193290; 18988627
19	SLEIQGQYSDINNRW	PhosphoSitePlus	22135298
31	NRWDLPDSDWDNDSS	PhosphoSitePlus;UniProt;curated	22135298; 24275569; 20873877; 22798277
37	DSDWDNDSSSARLFE	curated	20873877
75	NSHLARVTCRVGDLY	PhosphoSitePlus	22135298
82	TCRVGDLYSDLRDGR	PhosphoSitePlus	22135298
83	CRVGDLYSDLRDGRN	PhosphoSitePlus;curated	22135298; 22817900
99	LRLLEVLSGEILPKP	PhosphoSitePlus	22135298
166	RFQIQDISVETEDNK	dbPTM 3.0;HPRD 9;PhosphoSitePlus;curated	20068231; 16381945; 23193290; 18988627; 22135298; 24732914
268	VDQPDEKSIITYVAT	curated	22817900
277	ITYVATYYHYFSKMK	PhosphoSitePlus	22135298
449	SENQRLVSQDNFGLE	PhosphoSitePlus	22135298
477	IETDIVAYSGRVQAV	PhosphoSitePlus	22135298
691	TALRGEMSGRLGPLK	PhosphoSitePlus	22135298
771	VDALRLVSSPELGHD	curated	25849741
772	DALRLVSSPELGHDE	PhosphoSitePlus;curated	22135298; 23186163; 25849741
834	VPTLERHYEELQARA	PhosphoSitePlus	22135298
959	AALTSALSIQNYHLE	PhosphoSitePlus;UniProt	22135298; 24275569
1060	TMRRREESLGEARRL	PhosphoSitePlus	22135298
1073	RLQDFLRSLDDFQAW	PhosphoSitePlus;UniProt	22135298; 24275569

Sequence
(Fasta)

MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK 60
KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG EILPKPTKGR MRIHCLENVD 120
KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD 180
ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA 240
FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA 300
MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT 360
EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ 420
EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR 480
VQAVDAVAAE LAAERYHDIK RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL 540
LYLMDWMEEM KGRLQSQDLG RHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCNP 600
GKEYRPCDPQ LVSERVAKLE QSYEALCELA AARRARLEES RRLWRFLWEV GEAEAWVREQ 660
QHLLASADTG RDLTGALRLL NKHTALRGEM SGRLGPLKLT LEQGQQLVAE GHPGASQASA 720
RAAELQAQWE RLEALAEERA QRLAQAASLY QFQADANDME AWLVDALRLV SSPELGHDEF 780
STQALARQHR ALEEEIRSHR PTLDALREQA AALPPTLSRT PEVQSRVPTL ERHYEELQAR 840
AGERARALEA ALALYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE 900
MNTLAAQITA VNDIAEQLLK ANPPGKDRIV NTQEQLNHRW QQFRRLADGK KAALTSALSI 960
QNYHLECTET QAWMREKTKV IESTQGLGND LAGVLALQRK LAGTERDLEA IAARVGELTR 1020
EANALAAGHP AQAVAINARL REVQTGWEDL RATMRRREES LGEARRLQDF LRSLDDFQAW 1080
LGRTQTAVAS EEGPATLPEA EALLAQHAAL RGEVERAQSE YSRLRALGEE VTRDQADPQC 1140
LFLRQRLEAL GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM 1200
PGTLQAADAA IKKLEDFMST MDANGERIHG LLEAGRQLVS EGNIHADKIR EKADSIERRH 1260
KKNQDAAQQF LGRLRDNREQ QHFLQDCHEL KLWIDEKMLT AQDVSYDEAR NLHTKWQKHQ 1320
AFMAELAANK DWLDKVDKEG RELTLEKPEL KALVSEKLRD LHRRWDELET TTQAKARSLF 1380
DANRAELFAQ SCCALESWLE SLQAQLHSDD YGKDLTSVNI LLKKQQMLEW EMAVREKEVE 1440
AIQAQAKALA QEDQGAGEVE RTSRAVEEKF RALCQPMRER CRRLQASREQ HQFHRDVEDE 1500
ILWVTERLPM ASSMEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLRER QRALGAAAAG 1560
PELAELQEMW KRLGHELELR GKRLEDALRA QQFYRDAAEA EAWMGEQELH MMGQEKAKDE 1620
LSAQAEVKKH QVLEQALADY AQTIHQLAAS SQDMIDHEHP ESTRISIRQA QVDKLYAGLK 1680
ELAGERRERL QEHLRLCQLR RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS 1740
RDTSTIGQER VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA 1800
YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ ALSPQVQQVQ 1860
DDGHRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR QLLLDTTDKF RFFKAVRELM 1920
LWMDEVNLQM DAQERPRDVS SADLVIKNQQ GIKAEIEARA DRFSSCIDMG KELLARSHYA 1980
AEEISEKLSQ LQARRQETAE KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE 2040
LGCTVDEVES LIKRHEAFQK SAVAWEERFC ALEKLTALEE REKERKRKRE EEERRKQPPA 2100
PEPTASVPPG DLVGGQTASD TTWDGTQPRP PPSTQAPSVN GVCTDGEPSQ PLLGQQRLEH 2160
SSFPEGPGPG SGDEANGPRG ERQTRTRGPA PSAMPQSRST ESAHAATLPP RGPEPSAQEQ 2220
MEGMLCRKQE MEAFGKKAAN RSWQNVYCVL RRGSLGFYKD AKAASAGVPY HGEVPVSLAR 2280
AQGSVAFDYR KRKHVFKLGL QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSASGEPEEP 2340
VVPSTTRGMT RAMTMPPVSP VGAEGPVVLR SKDGRERERE KRFSFFKKNK 2391

Fasta Sequence

>O15020|SPTBN2|Homo sapiens(Human)
MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQSRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0117--Actin capping
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0950--Spinocerebellar ataxia

Interpro

IPR001589--Actinin_actin-bd_CS
IPR001715--CH-domain
IPR011993--PH/PTB_dom
IPR001605--PH_dom-spectrin-type
IPR001849--PH_domain
IPR018159--Spectrin/alpha-actinin
IPR016343--Spectrin_bsu
IPR002017--Spectrin_repeat

PROSITE

PS00019--ACTININ_1
PS00020--ACTININ_2
PS50021--CH
PS50003--PH_DOMAIN

Pfam

PF00307--CH
PF00435--Spectrin

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005615--C:extracellular space
GO:0043025--C:neuronal cell body
GO:0008091--C:spectrin
GO:0003779--F:actin binding
GO:0005543--F:phospholipid binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0051693--P:actin filament capping
GO:0000186--P:activation of MAPKK activity
GO:0030534--P:adult behavior
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0007411--P:axon guidance
GO:0021692--P:cerebellar Purkinje cell layer morphogenesis
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0035264--P:multicellular organism growth
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0007265--P:Ras protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0007416--P:synapse assembly
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016192--P:vesicle-mediated transport