dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000819
Uniprot Accession O15013; ARHGA_HUMAN; O14665; Q2KHR8; Q68D55; Q8IWD9; Q8IY77;
Genbank Protein ID NP_001295081.1; NP_001295082.1; NP_055444.2;
Genbank Nucleotide ID NM_001308152.1; NM_001308153.1; NM_014629.3;
Protein Name Rho guanine nucleotide exchange factor 10
Protein Synonyms/Alias
Gene Name ARHGEF10
Gene Synonyms/Alias KIAA0294;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play a role in developmental myelination of peripheral nerves.
Phosphorylation Sites
 dbPAF PTMs: 40 (View all)
PositionPeptidesSourceReferences ( PMIDs )
59GEQFDFDSGDEIPEAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664995; 21406692; 16381945; 23193290; 18988627; 22135298;
98EDGAGAETTPVAEPTcurated25627689
99DGAGAETTPVAEPTKPhosphoSitePlus;curated22135298; 25627689
198TEDRQPNSLSSEEPPcurated23663014
200DRQPNSLSSEEPPTScurated23663014
201RQPNSLSSEEPPTSEcurated23663014
239ENPEEAIYDDVPRENPhosphoSitePlus22135298
373AAVKRGRSFIRTKSLPhosphoSitePlus22135298
377RGRSFIRTKSLIAQDcurated25003641
379RSFIRTKSLIAQDHRdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated19276368; 20068231; 20363803; 20815410; 21406692; 16381945;
428VRRYILGSVVDSEKNcurated22817900
432ILGSVVDSEKNYVDAPhosphoSitePlus;curated22135298; 22817900
452EQYEKPLSEMEPKVLPhosphoSitePlus22135298
629AKAINERYLNKLLSSPhosphoSitePlus22135298
636YLNKLLSSGSRYLIRPhosphoSitePlus22135298
640LLSSGSRYLIRSDDMPhosphoSitePlus22135298
677NDVLMCATVSSRPSHdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
710GHVDAIEYGSSAGTGPhosphoSitePlus22135298
720SAGTGEHSRHLAVHPPhosphoSitePlus22135298
783NYQNLNQSVAHDWTScurated20873877
Sequence
(Fasta)		MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE EGEQFDFDSG 60
DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP VAEPTKLVLP MKVNPYSVID 120
ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL VPVPCGYAVP SNLPLLLPAY SSPVIICATS 180
LDEEAETPEV TEDRQPNSLS SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD 240
DVPRENSDSE PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR 300
SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV KAAKDGTKDG 360
LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD CKHPEAILTP MPEGLSQQQV 420
VRRYILGSVV DSEKNYVDAL KRILEQYEKP LSEMEPKVLS ERKLKTVFYR VKEILQCHSL 480
FQIALASRVS EWDSVEMIGD VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL 540
EFLKQEQEAS PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET 600
LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET VYNDRGEIVK 660
TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV PLGHVDAIEY GSSAGTGEHS 720
RHLAVHPPES LAVVANAKPN KVYMGPGQLY QDLQNLLHDL NVIGQITQLI GNLKGNYQNL 780
NQSVAHDWTS GLQRLILKKE DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK 840
ESWVNSLQMA KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIECAA 900
YNPEPYLNNE SQPDSFSTAH GFLWIGSCTH QMGQIAIVSF QNSTPKVIEC FNVESRILCM 960
LYVPVEEKRR EPGAPPDPET PAVRASDVPT ICVGTEEGSI SIYKSSQGSK KVRLQHFFTP 1020
EKSTVMSLAC TSQSLYAGLV NGAVASYARA PDGSWDSEPQ KVIKLGVLPV RSLLMMEDTL 1080
WAASGGQVFI ISVETHAVEG QLEAHQEEGM VISHMAVSGV GIWIAFTSGS TLRLFHTETL 1140
KHLQDINIAT PVHNMLPGHQ RLSVTSLLVC HGLLMVGTSL GVLVALPVPR LQGIPKVTGR 1200
GMVSYHAHNS PVKFIVLATA LHEKDKDKSR DSLAPGPEPQ DEDQKDALPS GGAGSSLSQG 1260
DPDAAIWLGD SLGSMTQKSD LSSSSGSLSL SHGSSSLEHR SEDSTIYDLL KDPVSLRSKA 1320
RRAKKAKASS ALVVCGGQGH RRVHRKARQP HQEELAPTVM VWQIPLLNI
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0344--Guanine-nucleotide releasing factor
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR030632--ARHGEF10
IPR000219--DH-domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50010--DH_2
Pfam

PF00621--RhoGEF
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0019894--F:kinesin binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0090630--P:activation of GTPase activity
GO:0051298--P:centrosome duplication
GO:0090307--P:mitotic spindle assembly
GO:0022011--P:myelination in peripheral nervous system
GO:0051496--P:positive regulation of stress fiber assembly
GO:0035023--P:regulation of Rho protein signal transduction