dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000818
Uniprot Accession O14994; SYN3_HUMAN; B1B1F9;
Genbank Protein ID NP_003481.3; NP_598344.2; XP_011528707.1; XP_011528708.1; XP_011528709.1; XP_011528710.1; XP_011528711.1;
Genbank Nucleotide ID NM_003490.3; NM_133633.2; XM_011530405.1; XM_011530406.1; XM_011530407.1; XM_011530408.1; XM_011530409.1;
Protein Name Synapsin-3
Protein Synonyms/Alias Synapsin III;
Gene Name SYN3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May be involved in the regulation of neurotransmitter release and synaptogenesis.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
32LQRPDSSTSSPASPAPhosphoSitePlus22135298
453QSPQPQRSGSPSQQRPhosphoSitePlus22135298
455PQPQRSGSPSQQRLSPhosphoSitePlus22135298
457PQRSGSPSQQRLSPQPhosphoSitePlus22135298
462SPSQQRLSPQGQQPLPhosphoSitePlus;curated22135298; 22817900
470PQGQQPLSPQSGSPQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated14732590; 16381945; 23193290; 15900227; 18988627; 22135298;
473QQPLSPQSGSPQQQRPhosphoSitePlus;curated22135298; 22817900
475PLSPQSGSPQQQRSPPhosphoSitePlus;curated22135298; 25850435; 22817900
484QQQRSPGSPQLSRASdbPTM 3.0;PhosphoSitePlus;curated20886841; 16381945; 23193290; 22135298; 25849741
508KPGATLASQPRPPVQcurated20873877
518RPPVQGRSTSQQGEEcurated20873877
520PVQGRSTSQQGEESKcurated20873877
545KSQSLTNSLSTSDTSPhosphoSitePlus22135298
552SLSTSDTSQRGTPSEPhosphoSitePlus22135298
Sequence
(Fasta)		MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF 60
SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA HTDWSKYFHG KKVNGEIEIR 120
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVSRSFKPD FILVRQHAYS MALGEDYRSL 180
VIGLQYGGLP AVNSLYSVYN FCSKPWVFSQ LIKIFHSLGP EKFPLVEQTF FPNHKPMVTA 240
PHFPVVVKLG HAHAGMGKIK VENQLDFQDI TSVVAMAKTY ATTEAFIDSK YDIRIQKIGS 300
NYKAYMRTSI SGNWKANTGS AMLEQVAMTE RYRLWVDSCS EMFGGLDICA VKAVHSKDGR 360
DYIIEVMDSS MPLIGEHVEE DRQLMADLVV SKMSQLPMPG GTAPSPLRPW APQIKSAKSP 420
GQAQLGPQLG QPQPRPPPQG GPRQAQSPQP QRSGSPSQQR LSPQGQQPLS PQSGSPQQQR 480
SPGSPQLSRA SSGSSPNQAS KPGATLASQP RPPVQGRSTS QQGEESKKPA PPHPHLNKSQ 540
SLTNSLSTSD TSQRGTPSED EAKAETIRNL RKSFASLFSD 581
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0770--Synapse
Interpro

IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR016185--PreATP-grasp_dom
IPR001359--Synapsin
IPR020898--Synapsin_ATP-bd_dom
IPR019735--Synapsin_CS
IPR019736--Synapsin_P_site
IPR020897--Synapsin_pre-ATP-grasp_dom
PROSITE

PS00415--SYNAPSIN_1
PS00416--SYNAPSIN_2
Pfam

PF02078--Synapsin
PF02750--Synapsin_C
PF10581--Synapsin_N
Gene Ontology

GO:0030054--C:cell junction
GO:0097481--C:neuronal postsynaptic density
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0005524--F:ATP binding
GO:0003824--F:catalytic activity
GO:0007269--P:neurotransmitter secretion
GO:0032228--P:regulation of synaptic transmission, GABAergic