dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000816
Uniprot Accession O14986; PI51B_HUMAN; A8K9L9; B4DIG7; P78518; P78519; Q5T5K6; Q5T5K8; Q5T5K9; Q5VZ00; Q7KYT5; Q8NHQ5; Q92749;
Genbank Protein ID NP_001265182.1; NP_003549.1; XP_005252318.1; XP_005252319.1; XP_006717363.1; XP_006717364.1; XP_011517384.1; XP_011517385.1; XP_011517386.1; XP_011517387.1;
Genbank Nucleotide ID NM_001278253.1; NM_003558.3; XM_005252261.3; XM_005252262.3; XM_006717300.2; XM_006717301.1; XM_011519082.1; XM_011519083.1; XM_011519084.1; XM_011519085.1;
Protein Name Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Protein Synonyms/Alias
Gene Name PIP5K1B
Gene Synonyms/Alias STM7;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
2------MSSAAENGEPhosphoSitePlus22135298
3-----MSSAAENGEAPhosphoSitePlus22135298
105FGIKPDDYLYSICSEdbPTM 3.0;PhosphoSitePlus19553680; 16381945; 23193290; 22135298
405KIQALKASPSKKRCNdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated19369195; 16381945; 23193290; 21081558; 22135298; 23186163
413PSKKRCNSIAALKATPhosphoSitePlus;curated22135298; 23186163
421IAALKATSQEIVSSIPhosphoSitePlus;curated22135298; 23186163
445DLLTEGQSFSSLDEEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298
447LTEGQSFSSLDEEALdbPTM 3.0;PhosphoPep 2.019369195; 16381945; 23193290; 19060867
448TEGQSFSSLDEEALGdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus19369195; 16381945; 23193290; 21081558; 19060867; 22135298
485TISSSSLYVNEHYPHcurated19369195
Sequence
(Fasta)		MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV 60
ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP 120
GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG 180
INIRIVVMNN VLPRSMRMHF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF 240
DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ 300
KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID ILQSYRLMKK 360
LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT 420
SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS 480
SSSLYVNEHY PHDRPTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL 540
541
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR023610--PInositol-4-P-5-kinase
IPR027483--PInositol-4-P-5-kinase_C
IPR002498--PInositol-4-P-5-kinase_core
IPR027484--PInositol-4-P-5-kinase_N
IPR016034--PInositol-4P-5-kinase_core_sub
PROSITE

PS51455--PIPK
Pfam

PF01504--PIP5K
Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016020--C:membrane
GO:0001931--C:uropod
GO:0016308--F:1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524--F:ATP binding
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0006644--P:phospholipid metabolic process
GO:0044281--P:small molecule metabolic process