dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000815
Uniprot Accession O14983; AT2A1_HUMAN; A8K5J9; B3KY17; O14984;
Genbank Protein ID NP_001273004.1; NP_004311.1; NP_775293.1;
Genbank Nucleotide ID NM_001286075.1; NM_004320.4; NM_173201.3;
Protein Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Protein Synonyms/Alias
Gene Name ATP2A1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
19CLAYFGVSETTGLTPPhosphoSitePlus22135298
122AIEALKEYEPEMGKVPhosphoSitePlus22135298
170IRILAIKSTTLRVDQPhosphoSitePlus22135298
178TTLRVDQSILTGESVHPRD 9;curated20068231; 18988627
184QSILTGESVSVIKHTPhosphoSitePlus;curated22135298; 20068231
186ILTGESVSVIKHTEPdbPTM 3.0;PhosphoSitePlus19628462; 16381945; 23193290; 22135298
191SVSVIKHTEPVPDPRPhosphoSitePlus22135298
261DEFGEQLSKVISLICPhosphoSitePlus22135298
335KKNAIVRSLPSVETLPhosphoSitePlus22135298
345SVETLGCTSVICSDKPhosphoSitePlus22135298
346VETLGCTSVICSDKTPhosphoSitePlus22135298
446EATETALTTLVEKMNdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
473ERANACNSVIRQLMKPhosphoSitePlus22135298
484QLMKKEFTLEFSRDRPhosphoSitePlus22135298
488KEFTLEFSRDRKSMSPhosphoSitePlus22135298
495SRDRKSMSVYCSPAKPhosphoSitePlus22135298
497DRKSMSVYCSPAKSSPhosphoSitePlus22135298
527GVIDRCNYVRVGTTRPhosphoSitePlus22135298
581EEMVLDDSARFLEYEPhosphoSitePlus22135298
608DPPRKEVTGSIQLCRPhosphoSitePlus22135298
Sequence
(Fasta)		MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL 60
LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 120
EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 180
TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 240
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 300
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 420
NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 480
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 540
VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 600
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 660
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 720
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 780
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 840
GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 900
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 960
ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR K 1002
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0106--Calcium
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR006068--ATPase_P-typ_cation-transptr_C
IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR005782--P-type_ATPase_IIA
IPR001757--P_typ_ATPase
IPR030332--SERCA1
PROSITE

PS00154--ATPASE_E1_E2
Pfam

PF00689--Cation_ATPase_C
PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase
PF08282--Hydrolase_3
Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0005793--C:endoplasmic reticulum-Golgi intermediate compartment
GO:0031673--C:H zone
GO:0031674--C:I band
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0031095--C:platelet dense tubular network membrane
GO:0016529--C:sarcoplasmic reticulum
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0005509--F:calcium ion binding
GO:0005388--F:calcium-transporting ATPase activity
GO:0042803--F:protein homodimerization activity
GO:0008637--P:apoptotic mitochondrial changes
GO:0007596--P:blood coagulation
GO:0070509--P:calcium ion import
GO:0070588--P:calcium ion transmembrane transport
GO:0006816--P:calcium ion transport
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0034220--P:ion transmembrane transport
GO:0051659--P:maintenance of mitochondrion location
GO:0032471--P:negative regulation of endoplasmic reticulum calcium ion concentration
GO:0045988--P:negative regulation of striated muscle contraction
GO:0032470--P:positive regulation of endoplasmic reticulum calcium ion concentration
GO:0031448--P:positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0051561--P:positive regulation of mitochondrial calcium ion concentration
GO:0006942--P:regulation of striated muscle contraction
GO:0090076--P:relaxation of skeletal muscle
GO:0034976--P:response to endoplasmic reticulum stress
GO:0055085--P:transmembrane transport