dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000814
Uniprot Accession O14981; BTAF1_HUMAN; B4E0W6; O43578;
Genbank Protein ID NP_003963.1;
Genbank Nucleotide ID NM_003972.2;
Protein Name TATA-binding protein-associated factor 172
Protein Synonyms/Alias ATP-dependent helicase BTAF1;B-TFIID transcription factor-associated 170 kDa subunit;TAF(II)170;TBP-associated factor 172;TAF-172;
Gene Name BTAF1
Gene Synonyms/Alias TAF172;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
87PRTRQEPTSESSMEDPhosphoSitePlus;curated22135298; 23090842
88RTRQEPTSESSMEDSPhosphoSitePlus22135298
91QEPTSESSMEDSPTTPhosphoSitePlus;curated22135298; 23090842
95SESSMEDSPTTERLNPhosphoSitePlus;curated22135298; 25850435; 23917254
97SSMEDSPTTERLNFDPhosphoSitePlus22135298
98SMEDSPTTERLNFDRPhosphoSitePlus22135298
224KLFAKQRSRDAVETNPhosphoSitePlus22135298
237TNEKSNDSTDGEPEEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated15302935; 16381945; 23193290; 18988627; 19060867; 22135298;
257ANVVINQSANDSKVLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18988627; 21081558; 19060867;
261INQSANDSKVLIDNIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19691289; 16381945; 23193290; 18988627; 22135298; 25627689;
415GGLLGIKYALAVRQDdbPTM 3.0;PhosphoSitePlus;curated18083107; 19658100; 16381945; 23193290; 22135298; 22817900
426VRQDVINTLLPKVLTPhosphoSitePlus22135298
884IIKPLMETIKKEENTPhosphoSitePlus22135298
974HRGIITLYRHQKAAFdbPTM 3.0;PhosphoSitePlus;curated18083107; 18180459; 16381945; 23193290; 22135298; 22817900
1256DGKKLENYKIPVPINdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
1359EYLNPLHYTGPPTERdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated17053785; 16381945; 23193290; 19060867; 22135298; 22817900
1400FRNIKFNYCILDEGHPhosphoSitePlus22135298
1465ERQFAARYGKPILASPhosphoSitePlus22135298
1472YGKPILASRDARSSSPhosphoSitePlus22135298
1477LASRDARSSSREQEAcurated23898821
Sequence
(Fasta)		MAVSRLDRLF ILLDTGTTPV TRKAAAQQLG EVVKLHPHEL NNLLSKVLIY LRSANWDTRI 60
AAGQAVEAIV KNVPEWNPVP RTRQEPTSES SMEDSPTTER LNFDRFDICR LLQHGASLLG 120
SAGAEFEVQD EKSGEVDPKE RIARQRKLLQ KKLGLNMGEA IGMSTEELFN DEDLDYTPTS 180
ASFVNKQPTL QAAELIDSEF RAGMSNRQKN KAKRMAKLFA KQRSRDAVET NEKSNDSTDG 240
EPEEKRRKIA NVVINQSAND SKVLIDNIPD SSSLIEETNE WPLESFCEEL CNDLFNPSWE 300
VRHGAGTGLR EILKAHGKSG GKMGDSTLEE MIQQHQEWLE DLVIRLLCVF ALDRFGDFVS 360
DEVVAPVRET CAQTLGVVLK HMNETGVHKT VDVLLKLLTQ EQWEVRHGGL LGIKYALAVR 420
QDVINTLLPK VLTRIIEGLQ DLDDDVRAVA AASLVPVVES LVYLQTQKVP FIINTLWDAL 480
LELDDLTAST NSIMTLLSSL LTYPQVQQCS IQQSLTVLVP RVWPFLHHTI SSVRRAALET 540
LFTLLSTQDQ NSSSWLIPIL PDMLRHIFQF CVLESSQEIL DLIHKVWMEL LSKASVQYVV 600
AAACPWMGAW LCLMMQPSHL PIDLNMLLEV KARAKEKTGG KVRQGQSQNK EVLQEYIAGA 660
DTIMEDPATR DFVVMRARMM AAKLLGALCC CICDPGVNVV TQEIKPAESL GQLLLFHLNS 720
KSALQRISVA LVICEWAALQ KECKAVTLAV QPRLLDILSE HLYYDEIAVP FTRMQNECKQ 780
LISSLADVHI EVGNRVNNNV LTIDQASDLV TTVFNEATSS FDLNPQVLQQ LDSKRQQVQM 840
TVTETNQEWQ VLQLRVHTFA ACAVVSLQQL PEKLNPIIKP LMETIKKEEN TLVQNYAAQC 900
IAKLLQQCTT RTPCPNSKII KNLCSSLCVD PYLTPCVTCP VPTQSGQENS KGSTSEKDGM 960
HHTVTKHRGI ITLYRHQKAA FAITSRRGPT PKAVKAQIAD LPAGSSGNIL VELDEAQKPY 1020
LVQRRGAEFA LTTIVKHFGG EMAVKLPHLW DAMVGPLRNT IDINNFDGKS LLDKGDSPAQ 1080
ELVNSLQVFE TAAASMDSEL HPLLVQHLPH LYMCLQYPST AVRHMAARCV GVMSKIATME 1140
TMNIFLEKVL PWLGAIDDSV KQEGAIEALA CVMEQLDVGI VPYIVLLVVP VLGRMSDQTD 1200
SVRFMATQCF ATLIRLMPLE AGIPDPPNMS AELIQLKAKE RHFLEQLLDG KKLENYKIPV 1260
PINAELRKYQ QDGVNWLAFL NKYKLHGILC DDMGLGKTLQ SICILAGDHC HRAQEYARSK 1320
LAECMPLPSL VVCPPTLTGH WVDEVGKFCS REYLNPLHYT GPPTERIRLQ HQVKRHNLIV 1380
ASYDVVRNDI DFFRNIKFNY CILDEGHVIK NGKTKLSKAV KQLTANYRII LSGTPIQNNV 1440
LELWSLFDFL MPGFLGTERQ FAARYGKPIL ASRDARSSSR EQEAGVLAMD ALHRQVLPFL 1500
LRRMKEDVLQ DLPPKIIQDY YCTLSPLQVQ LYEDFAKSRA KCDVDETVSS ATLSEETEKP 1560
KLKATGHVFQ ALQYLRKLCN HPALVLTPQH PEFKTTAEKL AVQNSSLHDI QHAPKLSALK 1620
QLLLDCGLGN GSTSESGTES VVAQHRILIF CQLKSMLDIV EHDLLKPHLP SVTYLRLDGS 1680
IPPGQRHSIV SRFNNDPSID VLLLTTHVGG LGLNLTGADT VVFVEHDWNP MRDLQAMDRA 1740
HRIGQKRVVN VYRLITRGTL EEKIMGLQKF KMNIANTVIS QENSSLQSMG TDQLLDLFTL 1800
DKDGKAEKAD TSTSGKASMK SILENLSDLW DQEQYDSEYS LENFMHSLK
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR022707--DUF3535
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF12054--DUF3535
PF00271--Helicase_C
PF00176--SNF2_N
Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0035562--P:negative regulation of chromatin binding
GO:0045892--P:negative regulation of transcription, DNA-templated